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American Journal of Epidemiology Vol. 154, No. 2 : 174-179
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health

ORIGINAL CONTRIBUTIONS

Statistical Inference for the Area under the Receiver Operating Characteristic Curve in the Presence of Random Measurement Error

Enrique F. Schisterman1, David Faraggi2, Benjamin Reiser2 and Maurizio Trevisan1

1 Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY.
2 Department of Statistics, Haifa University, Haifa, Israel.

The area under the receiver operating characteristic curve is the most commonly used measure of the ability of a biomarker to distinguish between two populations. Some markers are subject to substantial measurement error. Under normality assumptions, the authors develop a confidence interval procedure for the area under the receiver operating characteristic curve that adjusts for measurement error. This procedure assumes the availability of data from a reliability study of the biomarker. A simulation study was used to check the validity of the proposed confidence interval. Furthermore, it was shown that not adjusting for measurement error could result in a serious understatement of the effectiveness of the biomarker.

cardiovascular diseases; reliability; repeated measures; thiobarbituric acid reaction substances

Abbreviations: ROC, receiver operating characteristic; TBARS, thiobarbituric acid reaction substances


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