American Journal of Epidemiology Vol. 153, No. 9 : 921-924
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Screening without a "Gold Standard": The Hui-Walter Paradigm Revisited
1 Department of Statistics, University of California, Davis, CA.
2 Department of Statistics, George Washington University, Washington, DC.
3 Department of Mathematics and Statistics, Minnesota State University, Mankato, MN.
Correspondence to Dr. Wesley O. Johnson, Division of Statistics and Graduate Group in Epidemiology, University of California, One Shields Avenue, Davis, CA 95616-8705 (e-mail: wojohnson{at}ucdavis.edu).
The authors consider screening populations with two screening tests but where a definitive "gold standard" is not readily available. They discuss a recent article in which a Bayesian approach to this problem is developed based on data that are sampled from a single population. It was subsequently pointed out that such inferences will not necessarily be accurate in the sense that standard errors for parameters may not decrease as n increases. This problem will generally occur when the data are insufficient to estimate all of the parameters as is the case when screening a single population with two tests. If both tests are applied to units sampled from two populations, however, this particular difficulty disappears. In this article the authors further examine this issue and develop an approach based on sampling two populations that yields increasingly accurate inferences as the sample size increases.
Bayesian approach; diagnostic test; Gibbs sampler; likelihood; prevalence; sensitivity and specificity
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Elvinger, B. L. Akey, D. A. Senne, F. W. Pierson, B. A. Porter-Spalding, E. Spackman, and D. L. Suarez Characteristics of diagnostic tests used in the 2002 low-pathogenicity avian influenza H7N2 outbreak in Virginia J Vet Diagn Invest, July 1, 2007; 19(4): 341 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. H. Zou, A. J. O'Malley, and L. Mauri Receiver-Operating Characteristic Analysis for Evaluating Diagnostic Tests and Predictive Models Circulation, February 6, 2007; 115(5): 654 - 657. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chen, P. Watson, and G. Parmigiani Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard Biostat., July 1, 2005; 6(3): 450 - 464. [Abstract] [Full Text] [PDF]
|
|