American Journal of Epidemiology Vol. 153, No. 4 : 353-362
Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Coffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials
1 Department of Epidemiology and Disease Control, Yonsei University Graduate School of Health Science and Management, Seoul, Republic of Korea.
2 Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine, Baltimore, MD.
3 Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD.
4 Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
5 Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.
6 Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Republic of Korea.
7 Department of Health Policy and Management, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD.
Coffee drinking has been associated with increased serum cholesterol levels in some, but not all, studies. A Medline search of the English-language literature published prior to December 1998, a bibliography review, and consultations with experts were performed to identify 14 published trials of coffee consumption. Information was abstracted independently by two reviewers using a standardized protocol. With a random-effects model, treatment effects were estimated by pooling results from individual trials after weighting the results by the inverse of total variance. A dose-response relation between coffee consumption and both total cholesterol and LDL cholesterol was identified (p < 0.01). Increases in serum lipids were greater in studies of patients with hyperlipidemia and in trials of caffeinated or boiled coffee. Trials using filtered coffee demonstrated very little increase in serum cholesterol. Consumption of unfiltered, but not filtered, coffee increases serum levels of total and LDL cholesterol.
clinical trials; coffee; lipids; meta-analysis
Abbreviations: CI, confidence interval; HDL cholesterol, high density lipoprotein cholesterol; LDL cholesterol, low density lipoprotein cholesterol
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