American Journal of Epidemiology Vol. 152, No. 8 : 701-703
Copyright © 2000 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Invited Commentary: On Studying the Joint Effects of Candidate Genes and Exposures
From the Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
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INTRODUCTION |
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For a long time, epidemiologists have recognized that human disease arises from the interplay of environmental exposures and host susceptibilities. With recent advances in molecular biology, assessment of genetic contributions to susceptibility has progressed from indirect measures based on family history to direct measures of an individual's genotype at particular loci. With a draft sequence for the entire human genome in hand, medical science is poised for rapid advances in the study of how genetic susceptibility modulates risk from environmental exposures.
The goal of gene-environment studies in epidemiology is to learn how the risk of a disease changes as a joint function of genotype and exposure. Such studies promise new insights into etiology. They also promise the eventual capability to tailor interventions more precisely, whether at a clinical level, where the therapeutic agent prescribed or its dose may be chosen in light of an individual's genetic makeup, or at a
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CONFOUNDING |
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BIOLOGIC PLAUSIBILITY |
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A FINAL REMARK |
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NOTES |
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REFERENCES |
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