American Journal of Epidemiology, Vol 152, Issue 6 497-505, Copyright © 2000 by Oxford University Press
K Bromen, H Pohlabeln, I Jahn, W Ahrens and KH Jockel
The authors investigated familial aggregation of lung cancer by means of a
population-based case-control study, conducted in Germany between 1988 and
1993. They compared lung cancer prevalence in first degree relatives of 945
patients and 983 controls, accounting for various potential risk factors
using logistic regression and generalized estimating equations. Some 83% of
the study participants were male, and about 14% were below age 51 (young
age group). Overall, lung cancer in parents or siblings was associated with
a 1.67-fold (95% confidence interval (CI): 1.11, 2.52) increase in lung
cancer risk. For the young participants, this risk was 4.75 (95% CI: 1.20,
18.77). Having multiple affected relatives (two or more) was related to a
threefold risk elevation (odds ratio (OR) = 2.99, 95% CI: 0.32, 27.55).
Paternal (OR = 1.64, 95% CI: 0.91, 2.96) but not maternal (OR = 0.91, 95%
CI: 0.32, 2.61) lung cancer was associated with an increased risk of the
disease. Lung cancer risk from smoking was particularly pronounced in the
parents of cases (OR = 12.20, 95% CI: 3.34, 44.62 vs. OR = 7.93, 95% CI:
2.43, 25.91 in parents of controls). No risk elevation was detected for
other smoking-related and other cancers in general. Results confirm
previous findings and support the etiologic role of a genetic
predisposition to lung cancer.
ARTICLES
Aggregation of lung cancer in families: results from a population-based case-control study in Germany
Institute of Medical Informatics, Biometry, and Epidemiology, University of Essen, Germany. katja.bromen@uni-essen.de
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