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American Journal of Epidemiology Vol. 152, No. 5 : 407-412
Copyright © 2000 by The Johns Hopkins University School of Hygiene and Public Health


ORIGINAL CONTRIBUTIONS

Invited Commentary: Particulate Matter-Mortality Exposure-Response Relations and Threshold

C. Arden Pope, III

From the Brigham Young University, Provo, UT.

Abbreviations: PM, particulate matter air pollution.


    INTRODUCTION
 
In this issue of the Journal, Daniels et al. (1Go) report an analysis of the shape of the exposure-response relation between daily concentrations of particulate matter air pollution (PM) and mortality. They provide additional epidemiologic evidence of the absence of a population-based "no-effects" threshold level for PM within relevant ranges of exposure. Their results suggest that the PM-mortality exposure-response relation is near linear, with mortality risk occurring even at concentrations below current regulatory levels. This analysis is the latest of several important contributions to the literature on particuate matter and mortality by Samet, Zeger, and various colleagues.

In the early 1990s, following the publications of several studies that suggested a link between daily mortality and PM pollution at relatively low concentrations (2GoGoGoGoGo–7Go), Samet and others argued that the findings could not be adequately interpreted and they encouraged new studies (8Go). Samet and Zeger then led . . . [Full Text of this Article]


    LITERATURE DEVELOPMENT
 
Early episode studies
Early time-series studies
Poisson regression, quintile plots, and nonparametric smoothing
Publication bias and measurement error

    CURRENT MULTICITY STUDIES
 

    RESPONSE TO LONGER-TERM PM EXPOSURE
 

    CONCLUSIONS
 

    NOTES
 

    REFERENCES
 

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Am. J. Epidemiol. 2000 152: 397-406. [Abstract] [FREE Full Text]  



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