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American Journal of Epidemiology Vol. 152, No. 4 : 389-392
Copyright © 2000 by The Johns Hopkins University School of Hygiene and Public Health

ORIGINAL CONTRIBUTIONS

Incidence of Influenza-like Illness, Measured by a General Practitioner Sentinel System, Is Associated with Day-to-day Variations in Respiratory Health in Panel Studies

Saskia C. van der Zee, Gerard Hoek and Bert Brunekreef

From the Environmental and Occupational Health Group, University of Wageningen, Wageningen, Netherlands.

During three consecutive winters beginning in 1992–1993, the association between the incidence of influenza and influenza-like illness (ILI), measured by a general practitioner sentinel system, and respiratory health was investigated in an air pollution panel study. Data from 22 panels of children (7–11 years old) and adults (50–70 years old) in the Netherlands were used. ILI incidence was associated with peak expiratory flow, respiratory symptoms, and bronchodilator use. Peak ILI incidence of 122 cases/10,000 subjects was associated with a decrement in peak expiratory flow of 6% and a 3- to 4.5-fold increase in symptom reporting and bronchodilator use. In panel studies, ILI incidence might be used to adjust for confounding by acute respiratory infections. Am J Epidemiol 2000;152:389–92.

influenza; longitudinal studies; respiration; viruses

Abbreviations: ILI, influenza and influenza-like illness


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