Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (77)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Checkley, W.
Right arrow Articles by Sterling, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Checkley, W.
Right arrow Articles by Sterling, C. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 148, No. 5: 497-506
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health

other

Effects of Cryptosporidium parvum Infection in Peruvian Children: Growth Faltering and Subsequent Catch-up Growth

William Checkley1,2, Leonardo D. Epstein3, Robert H. Gilman1,2,, Robert E. Black1, Lilia Cabrera2 and Charles R. Sterling4

1Department of International Health, Johns Hopkins School of Hygiene and Public Health Baltimore, MD
2Proyectos en Informatica, Salud, Medicina y Agricultura (Aso-ciacion Benefica PRISMA) Lima, Peru
3Departamento de Estadistica, Universidad Catolica de Chile Santiago, Chile
4Department of Veterinary Medicine, University of Arizona Tucson, AZ

Reprint requests to Dr. Robert H. Gilman, Department of International Health, Johns Hopkins School of Hygiene and Public Health, Room W3503, 615 N. Wolfe Street, Baltimore, MD 21205.

The authors conducted a 2–year (1989–1991) community-based longitudinal study in a shantytown in Lima, Peru, to examine the effect of Cryptosporidium parvum infection on child growth during the year following the onset of infection. A cohort of children, aged 0–3 months at recruitment, was followed monthly for anthropometries, weekly for stool samples, and daily for diarrheal status. Data from 185 children in the cohort permitted a comparison of growth in C. parvum-infected and noninfected children. The analyses fitted smooth, flexible curves with a linear random-effects model to estimate growth differences between C. parvum-infected and noninfected children. Children infected with C. parvum experienced growth faltering, both in weight and in height, for several months after the onset of infection, followed by a period of catch-up growth. Younger children took longer to catch up in weight than did older children. Catch-up growth, however, did not occur in children infected between ages 0 and 5 months. These children did not catch up in height, and one year after infection they exhibited an average deficit of 0.95 cm (95% confidence interval (Cl) 0.38–1.53) relative to noninfected children of similar age. Stunted children who became infected also did not catch up in either weight or height, and one year after infection they exhibited a height deficit of 1.05 cm (95% Cl 0.46–1.66) relative to noninfected, stunted children of similar age. These results indicate that Cryptosporidium parvum has a lasting adverse effect on linear (height) growth, especially when acquired during infancy and when children are stunted before they become infected. Am J Epidemiol 1998; 148:497–506.

Cryptosporidium parvum; diarrhea; infantile; growth disorders; infection; longitudinal studies; nutrition disorders; smoothing splines; statistics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int J EpidemiolHome page
W. Checkley, G. Buckley, R. H Gilman, A. M. Assis, R. L Guerrant, S. S Morris, K. Molbak, P. Valentiner-Branth, C. F Lanata, R. E Black, et al.
Multi-country analysis of the effects of diarrhoea on childhood stunting
Int. J. Epidemiol., August 1, 2008; 37(4): 816 - 830.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Pantenburg, S. M. Dann, H.-C. Wang, P. Robinson, A. Castellanos-Gonzalez, D. E. Lewis, and A. C. White Jr.
Intestinal Immune Response to Human Cryptosporidium sp. Infection
Infect. Immun., January 1, 2008; 76(1): 23 - 29.
[Full Text] [PDF]

Home page
 PediatricsHome page
K. Z. Long, J. L. Rosado, Y. Montoya, M. de Lourdes Solano, E. Hertzmark, H. L. DuPont, and J. I. Santos
Effect of Vitamin A and Zinc Supplementation on Gastrointestinal Parasitic Infections Among Mexican Children
Pediatrics, October 1, 2007; 120(4): e846 - e855.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
P. Marquet, L. Barbot, A. Plante, J. F. Huneau, J. G. Gobert, and N. Kapel
Cryptosporidiosis Induces a Transient Upregulation of the Oligopeptides Transporter (PepT1) Activity in Neonatal Rats
Experimental Biology and Medicine, March 1, 2007; 232(3): 454 - 460.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
J. L. TARLETON, R. HAQUE, D. MONDAL, J. SHU, B. M. FARR, and W. A. PETRI JR.
Cognitive effects of diarrhea, malnutrition, and entamoeba histolytica infection on school age children in dhaka, bangladesh.
Am J Trop Med Hyg, March 1, 2006; 74(3): 475 - 481.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. A. Rogers, A. B. Rogers, B. A. Leav, A. Sanchez, E. Vannier, S. Uematsu, S. Akira, D. Golenbock, and H. D. Ward
MyD88-Dependent Pathways Mediate Resistance to Cryptosporidium parvum Infection in Mice
Infect. Immun., January 1, 2006; 74(1): 549 - 556.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
J. W. Priest, C. Bern, L. Xiao, J. M. Roberts, J. P. Kwon, A. G. Lescano, W. Checkley, L. Cabrera, D. M. Moss, M. J. Arrowood, et al.
Longitudinal Analysis of Cryptosporidium Species-Specific Immunoglobulin G Antibody Responses in Peruvian Children
Clin. Vaccine Immunol., January 1, 2006; 13(1): 123 - 131.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
W. A. KHAN, K. A. ROGERS, M. M. KARIM, S. AHMED, P. L. HIBBERD, S. B. CALDERWOOD, E. T. RYAN, and H. D. WARD
CRYPTOSPORIDIOSIS AMONG BANGLADESHI CHILDREN WITH DIARRHEA: A PROSPECTIVE, MATCHED, CASE-CONTROL STUDY OF CLINICAL FEATURES, EPIDEMIOLOGY AND SYSTEMIC ANTIBODY RESPONSES
Am J Trop Med Hyg, October 1, 2004; 71(4): 412 - 419.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
L. Xiao, R. Fayer, U. Ryan, and S. J. Upton
Cryptosporidium Taxonomy: Recent Advances and Implications for Public Health
Clin. Microbiol. Rev., January 1, 2004; 17(1): 72 - 97.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
E. M. Santiago, E. Lawson, K. Gillenwater, S. Kalangi, A. G. Lescano, G. Du Quella, K. Cummings, L. Cabrera, C. Torres, and R. H. Gilman
A Prospective Study of Bacillus Calmette-Guerin Scar Formation and Tuberculin Skin Test Reactivity in Infants in Lima, Peru
Pediatrics, October 1, 2003; 112(4): e298 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
W. Checkley, L. D. Epstein, R. H. Gilman, L. Cabrera, and R. E. Black
Effects of Acute Diarrhea on Linear Growth in Peruvian Children
Am. J. Epidemiol., January 15, 2003; 157(2): 166 - 175.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. A. Leav, M. R. Mackay, A. Anyanwu, R. M. O' Connor, A. M. Cevallos, G. Kindra, N. C. Rollins, M. L. Bennish, R. G. Nelson, and H. D. Ward
Analysis of Sequence Diversity at the Highly Polymorphic Cpgp40/15 Locus among Cryptosporidium Isolates from Human Immunodeficiency Virus-Infected Children in South Africa
Infect. Immun., July 1, 2002; 70(7): 3881 - 3890.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
X.-M. Chen, J. S. Keithly, C. V. Paya, and N. F. LaRusso
Cryptosporidiosis
N. Engl. J. Med., May 30, 2002; 346(22): 1723 - 1731.
[Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
P. R. Hunter and G. Nichols
Epidemiology and Clinical Features of Cryptosporidium Infection in Immunocompromised Patients
Clin. Microbiol. Rev., January 1, 2002; 15(1): 145 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
S. Moore, A. Lima, M. Conaway, J. Schorling, A. Soares, and R. Guerrant
Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering
Int. J. Epidemiol., December 1, 2001; 30(6): 1457 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
Z. C. Luo and J. Karlberg
Critical Growth Phases for Adult Shortness
Am. J. Epidemiol., July 15, 2000; 152(2): 125 - 131.
[Abstract] [Full Text] [PDF]

Home page
 JWatch Infect. DiseasesHome page
Cryptosporidiosis Stunts Childhood Growth
Journal Watch Infectious Diseases, October 1, 1998; 1998(1001): 16 - 16.
[Full Text]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.