American Journal of Epidemiology Vol. 148, No. 5: 445-451
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health
other |
Donation of Blood Is Associated with Reduced Risk of Myocardial Infarction
The Kuopio Ischaemic Heart Disease Risk Factor Study
1Research Institute of Public Health, University of Kuopio Kuopio, Finland
2Department of Medicine, Kuopio University Hospital Kuopio, Finland
Reprint requests to Prof. Jukka T. Salonen, Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland.
Because high body iron stores have been suggested as a risk factor for acute myocardial infarction, donation of blood could theoretically reduce the risk by lowering body iron stores. For this reason, the authors tested the hypothesis that voluntary blood donation is associated with reduced risk of acute myocardial infarction in a prospective epidemiologic follow-up study in men from eastern Finland. The subjects are all participants of the Kuopio Ischaemic Heart Disease Risk Factor Study. A cohort of 2, 862 men aged 42–60 years were followed for an average of almost 9 years. One man (0.7%) out of 153 men who had donated blood in 24 months preceding the baseline examination experienced an acute myocardial infarction during 1984 to 1995, whereas 316 men (12.5%) of 2, 529 non-blood donors had an acute myocardial infarction (p < 0.0001 for difference between proportions). In a Cox proportional hazards model adjusting for age, examination years and all other predictive coronary disease risk factors, blood donors had a 88% reduced risk (relative hazard = 0.12, 95% confidence interval 0.02–0.86, p = 0.035) of acute myocardial infarction, compared with non-blood donors. These findings suggest that frequent blood loss through voluntary blood donations may be associated with a reduced risk of acute myocardial infarction in middle-aged men. Am J Epidemiol 1998; 148: 445–51.
cardiovascular diseases; iron; myocardial infarction; population studies; risk factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. l. Sullivan Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability Experimental Biology and Medicine, September 1, 2007; 232(8): 1014 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Vari, B. Balkau, A. Kettaneh, P. Andre, J. Tichet, F. Fumeron, E. Caces, M. Marre, B. Grandchamp, P. Ducimetiere, et al. Ferritin and Transferrin Are Associated With Metabolic Syndrome Abnormalities and Their Change Over Time in a General Population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Diabetes Care, July 1, 2007; 30(7): 1795 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Swaminathan, V. A. Fonseca, M. G. Alam, and S. V. Shah The Role of Iron in Diabetes and Its Complications Diabetes Care, July 1, 2007; 30(7): 1926 - 1933. [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Zacharski, B. K. Chow, P. S. Howes, G. Shamayeva, J. A. Baron, R. L. Dalman, D. J. Malenka, C. K. Ozaki, and P. W. Lavori Reduction of Iron Stores and Cardiovascular Outcomes in Patients With Peripheral Arterial Disease: A Randomized Controlled Trial JAMA, February 14, 2007; 297(6): 603 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sullivan Stored Iron and Vascular Reactivity Arterioscler Thromb Vasc Biol, August 1, 2005; 25(8): 1532 - 1535. [Full Text] [PDF]
|
|
|
|
 |
|
 G Pennings Demanding pure motives for donation: the moral acceptability of blood donations by haemochromatosis patients J. Med. Ethics, February 1, 2005; 31(2): 69 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E.R. Kartikasari, N. A. Georgiou, F. L.J. Visseren, H. van Kats-Renaud, B. S. van Asbeck, and J. J.M. Marx Intracellular Labile Iron Modulates Adhesion of Human Monocytes to Human Endothelial Cells Arterioscler Thromb Vasc Biol, December 1, 2004; 24(12): 2257 - 2262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. T. Alpert New and Emerging Theories of Cardiovascular Disease: Response to Commentaries Biol Res Nurs, July 1, 2004; 6(1): 21 - 23. [PDF]
|
|
|
|
 |
|
 G. Ramakrishna, T. W Rooke, and L. T Cooper Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light Vascular Medicine, August 1, 2003; 8(3): 203 - 210. [Abstract] [PDF]
|
|
|
|
 |
|
 M. W. Knuiman, M. L. Divitini, J. K. Olynyk, D. J. Cullen, and H. C. Bartholomew Serum Ferritin and Cardiovascular Disease: A 17-Year Follow-up Study in Busselton, Western Australia Am. J. Epidemiol., July 15, 2003; 158(2): 144 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Gaenzer, P. Marschang, W. Sturm, G.u. Neumayr, W. Vogel, J. Patsch, and G.u. Weiss Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis J. Am. Coll. Cardiol., December 18, 2002; 40(12): 2189 - 2194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T Sempos Do body iron stores increase the risk of developing coronary heart disease? Am. J. Clinical Nutrition, September 1, 2002; 76(3): 501 - 503. [Full Text] [PDF]
|
|
|
|
|
|
D. J. A. Jenkins, C. W. C. Kendall, L. S. A. Augustin, M. C. Martini, M. Axelsen, D. Faulkner, E. Vidgen, T. Parker, H. Lau, P. W. Connelly, et al. Effect of Wheat Bran on Glycemic Control and Risk Factors for Cardiovascular Disease in Type 2 Diabetes Diabetes Care, September 1, 2002; 25(9): 1522 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ma and M. J. Stampfer Body Iron Stores and Coronary Heart Disease Clin. Chem., April 1, 2002; 48(4): 601 - 603. [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sullivan, A. Ascherio, E. B. Rimm, E. Giovannucci, W. C. Willett, and M. J. Stampfer Blood Donation Without Adequate Iron Depletion: An Invalid Test of the Iron Hypothesis Circulation, December 11, 2001; 104 (24): e149 - e149. [Full Text] [PDF]
|
|
|
|
|
|
A. Ascherio, E. B. Rimm, E. Giovannucci, W. C. Willett, and M. J. Stampfer Blood Donations and Risk of Coronary Heart Disease in Men Circulation, January 2, 2001; 103(1): 52 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Froom Blood viscosity and th erisk of death from coronary heart disease Eur. Heart J., April 1, 2000; 21(7): 513 - 514. [PDF]
|
|
|
|
 |
|
 Other Articles Noted Evid. Based Nurs., October 1, 1999; 2(4): 105 - 112. [Full Text]
|
|
|
|
|
|
T.-P. Tuomainen, K. Kontula, K. Nyyssonen, T. A. Lakka, T. Helio, and J. T. Salonen Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation : A Prospective Cohort Study in Men in Eastern Finland Circulation, September 21, 1999; 100(12): 1274 - 1279. [Abstract] [Full Text] [PDF]
|
|