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American Journal of Epidemiology Vol. 148, No. 1: 45-50
Copyright © 1998 by The Johns Hopkins University School of Hygiene and Public Health

other

Cohort Study of Vitamin C Intake and Cognitive Impairment

Michael Paleologos, Robert G. Cumming and Ross Lazarus

From the Department of Public Health and Community Medicine, Faculty of Medicine, University of Sydney Sydney, Australia

Reprint requests to Dr. Robert G. Cumming, Department of Public Health and Community Medicine, Building A27, University of Sydney, Sydney, New South Wales 2006, Australia.

To test the hypothesis that vitamin C protects against cognitive impairment, the authors conducted a cohort study (n = 117) in a retirement community in Sydney, Australia. Vitamin C intake was assessed at baseline (1991) with a semiquantitative food frequency questionnaire, and cognitive function was assessed 4 years later (1995). After adjustment for age, sex, smoking, education, total energy intake, and use of psychotropic medications, consumption of vitamin C supplements was associated with a lower prevalence of more severe cognitive impairment (based on scores on the Mini-Mental State Examination; adjusted odds ratio = 0.39, 95% confidence interval 0.18–0.84). There were no associations between vitamin C intake and scores on tests of verbal and category fluency. This study suggests that vitamin C might protect against cognitive impairment. Am J Epidemiol 1998; 148: 45–50.

Alzheimer's disease; ascorbic acid; cohort studies; cognition; dementia


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