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American Journal of Epidemiology Vol. 146, No. 12: 1011-1018
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health

research-article

Plasma Apolipoprotein A-I, Apolipoprotein B, and Lipoprotein(a) Concentrations in Normoglycemic Hispanics and Non-Hispanic Whites from the San Luis Valley, Colorado

M. llyas Kamboh, Marian Rewers, Christopher E. Aston and Richard F. Hamman

1Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA
2Department of Preventive Medicine and Biometrics, University of Colorado Health Science Center Denver, CO

Reprint requests to Dr. M. llyas Kamboh, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261. Email: Ikamboh{at}helix.hgen.pitt.edu

Lower levels of plasma apolipoprotein (apo) A-I and higher levels of apoB, lipoprotein(a) (Lp(a)), and the ratio of apoB to apoA-I are considered to be independent risk factors for coronary heart disease. To examine race differences in the distributions of plasma levels of apoA-I, apoB, and Lp(a), the authors have determined quantitative levels of these traits in 252 nondiabetic Hispanics and 459 nondiabetic non-Hispanic whites (NHWs) from the San Luis Valley, Colorado. Hispanic men and women, respectively, had significantly higher plasma apoB levels (p < 0.003; p < 0.01) and the ratio of apoB to apoA-I (p < 0.003; p < 0.0003) than their NHW counterparts. Plasma Lp(a) concentrations were also significantly higher in Hispanic men (p < 0.003) and apoA-I levels were significantly lower in Hispanic women (p < 0.0003) than NHW men and women, respectively. Overall, the threshold points of apoA-l (<120 mg/dl), apoB (>120 mg/dl), and Lp(a) (>25 mg/dl) were higher in Hispanics than in NHWs for apoA-I (22.8 vs. 15.7%), apoB (16.9 vs. 9.9%), and Lp(a) (18.6 vs. 12.4%). These data suggest that the quantitative risk profile for coronary heart disease with respect to these three quantitative traits is not favorable for Hispanics compared with that for NHWs in the San Luis Valley, Colorado. Am J Epidemiol 1997;146:1011–18.

apolipoprotein A-I; apolipoproteins B; Hispanic Americans; whites


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