American Journal of Epidemiology Vol. 145, No. 4: 349-357
Copyright © 1997 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Tubal Ligation and Fatal Ovarian Cancer in a Large prospective Cohort Study
1Department of Epidemiology and Surveillance Research, American Cancer Society Atlanta, GA
2Department of Biostatistics, Emory University Rollins School of Public Health, Atlanta GA
Reprint requests to Dr. Eugenia Calle, Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, 1599 Clifton Road, NE, Atlanta, GA 30329-4251.
Several studies suggest that tubal sterilization may decrease the risk of ovarian cancer. Data from the Cancer Prevention Study II were analyzed to examine the relation between tubal ligation and ovarian cancer mortality in a large prospective study. A total of 396,114 women who had not had hysterectomies and who had no prior history of cancer (except nonmelanoma skin cancer) were followed prospectively for approximately 9 years from 1982 to 1991. During this time, 799 ovarian cancer deaths were observed. Tubal ligation was significantly associated with a decreased risk of ovarian cancer mortality in an age- and race-adjusted Cox proportional hazards model (hazard ratio (HR) = 0.64, 95% confidence interval (Cl) 0.42–0.96), and the results were essentially unchanged when controlling for potential ovarian cancer risk factors (HR = 0.68, 95% Cl 0.45–1.03). The protective effect appeared to be greater in the first 20 years after the procedure (HR = 0.49, 95% Cl 0.24–0.99) than later (HR = 0.80, 95% Cl 0.48–1.34). No interactions between ever having had a tubal ligation and other covariates were observed. These data suggest that tubal ligation reduces the risk of fatal ovarian cancer. Am J Epidemiol 1997; 145: 349–57.
cohort studies; ovarian neoplasms; sterilization, tubal
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. H. Greene, M. Piedmonte, D. Alberts, M. Gail, M. Hensley, Z. Miner, P. L. Mai, J. Loud, G. Rodriguez, J. Basil, et al. A Prospective Study of Risk-Reducing Salpingo-oophorectomy and Longitudinal CA-125 Screening among Women at Increased Genetic Risk of Ovarian Cancer: Design and Baseline Characteristics: A Gynecologic Oncology Group Study Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 594 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K Kjaer, L. Mellemkjaer, L. A Brinton, C. Johansen, G. Gridley, and J. H Olsen Tubal sterilization and risk of ovarian, endometrial and cervical cancer. A Danish population-based follow-up study of more than 65 000 sterilized women Int. J. Epidemiol., June 1, 2004; 33(3): 596 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Rutter, S. Wacholder, A. Chetrit, F. Lubin, J. Menczer, S. Ebbers, M. A. Tucker, J. P. Struewing, and P. Hartge Gynecologic Surgeries and Risk of Ovarian Cancer in Women With BRCA1 and BRCA2 Ashkenazi Founder Mutations: An Israeli Population-Based Case-Control Study J Natl Cancer Inst, July 16, 2003; 95(14): 1072 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Riman, P. W. Dickman, S. Nilsson, N. Correia, H. Nordlinder, C. M. Magnusson, and I. R. Persson Risk Factors for Invasive Epithelial Ovarian Cancer: Results from a Swedish Case-Control Study Am. J. Epidemiol., August 15, 2002; 156(4): 363 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Barnes, W. E. Grizzle, C. J. Grubbs, and E. E. Partridge Paradigms for Primary Prevention of Ovarian Carcinoma CA Cancer J Clin, July 1, 2002; 52(4): 216 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Ness and C. Cottreau Possible Role of Ovarian Epithelial Inflammation in Ovarian Cancer J Natl Cancer Inst, September 1, 1999; 91(17): 1459 - 1467. [Abstract] [Full Text] [PDF]
|
|