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American Journal of Epidemiology Vol. 144, No. 6: 537-547
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
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Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh Pittsburgh, PA
2Department of Pathology, University of Vermont Burlington, VT
3Multiple Risk Factor Intervention Group Coordinating Center Minneapolis, MN
4London School of Hygiene & Tropical Medicine London, United Kingdom
Reprint requests to Dr. Lewis H. Kuller, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St., Pittsburgh, PA 15261.
The authors measured the relation between C-reactive protein, 
1 acid glycoprotein and albumin, an acute phase protein, and subsequent risk of myocardial infarction and coronary heart disease death in a nested case-control study among the Multiple Risk Factor Intervention Trial (MRFIT) participants. There were 98 myocardial infarction cases, 148 coronary heart disease deaths, and 491 controls. The cases and controls were followed for up to 17 years for deaths and 6–7 years for myocardial infarction cases and controls. There was a significant association between available distribution of C-reactive protein and subsequent coronary heart disease mortality. For smokers at baseline, the risk of coronary heart disease deaths in quartile 4 of C-reactive protein as compared with quartile 1 was 4.3 (95% confidence interval 1.74–10.8). The association persisted when adjusted for characteristics related to smoking and smoking cessation during the trial and to pulmonary function. There was no relation between 1 acid glycoprotein and either myocardial infarction or coronary heart disease death. Albumin was inversely related to coronary heart disease death only for deaths that occurred between 7 and 13 years after baseline, consistent with previous MRFIT analyses. This is the first prospective study in "healthy but high risk individuals" to document the relation between C-reactive protein and coronary heart disease mortality. Am J Epidemiol 996; 144: 537–47.
acute phase proteins; albumins; coronary disease; C-reactive protein; orosomucoid; smoking
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|
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|
|
|
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|
|
|
|
 |
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
S. Melamed, A. Shirom, S. Toker, S. Berliner, and I. Shapira Association of Fear of Terror With Low-Grade Inflammation Among Apparently Healthy Employed Adults Psychosom Med, July 1, 2004; 66(4): 484 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kluft Identifying patients at risk of coronary vascular disease: the potential role of inflammatory markers Eur. Heart J. Suppl., July 1, 2004; 6(suppl_C): C21 - C27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taponen, H. Martikainen, M.-R. Jarvelin, U. Sovio, J. Laitinen, A. Pouta, A.-L. Hartikainen, M. I. McCarthy, S. Franks, M. Paldanius, et al. Metabolic Cardiovascular Disease Risk Factors in Women with Self-Reported Symptoms of Oligomenorrhea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2114 - 2118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 U. A. Ajani, E. S. Ford, and A. H. Mokdad Dietary Fiber and C-Reactive Protein: Findings from National Health and Nutrition Examination Survey Data J. Nutr., May 1, 2004; 134(5): 1181 - 1185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Danesh, J. G. Wheeler, G. M. Hirschfield, S. Eda, G. Eiriksdottir, A. Rumley, G. D.O. Lowe, M. B. Pepys, and V. Gudnason C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease N. Engl. J. Med., April 1, 2004; 350(14): 1387 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Tall C-Reactive Protein Reassessed N. Engl. J. Med., April 1, 2004; 350(14): 1450 - 1452. [Full Text] [PDF]
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 G. Block, C. Jensen, M. Dietrich, E. P. Norkus, M. Hudes, and L. Packer Plasma C-Reactive Protein Concentrations in Active and Passive Smokers: Influence of Antioxidant Supplementation J. Am. Coll. Nutr., April 1, 2004; 23(2): 141 - 147. [Abstract] [Full Text] [PDF]
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|
|
|
 |
|
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|
|
|
|
 |
|
 J. T. Lane Microalbuminuria as a marker of cardiovascular and renal risk in type 2 diabetes mellitus: a temporal perspective Am J Physiol Renal Physiol, March 1, 2004; 286(3): F442 - F450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 V. Fonseca, C. Desouza, S. Asnani, and I. Jialal Nontraditional Risk Factors for Cardiovascular Disease in Diabetes Endocr. Rev., February 1, 2004; 25(1): 153 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Backes, P. A Howard, and P. M Moriarty Role of C-Reactive Protein in Cardiovascular Disease Ann. Pharmacother., January 1, 2004; 38(1): 110 - 118. [Abstract] |