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American Journal of Epidemiology Vol. 143, No. 7: 665-676
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health
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Association of Fibrinogen and Coagulation Factors Vll and VIII with Cardiovascular Risk Factors in the Elderly
The Cardiovascular Health Study
1Department of Pathology and Medicine, University of Vermont Burlington, VT
2Department of Biostatistics, University of Washington Seattle, WA
3Departments of Medicine, Epidemiology, and Health Services, University of Washington Seattle, WA
4Departments of Medicine and Epidemiology, The Johns Hopkins University Baltimore, MD
5Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC
6Department of Medicine, University of California Davis, Davis, CA
7Department of Radiology, Brigham and Women's Hospital Boston, MA
8Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute Bethesda, MD
9Departments of Pathology and Biochemistry, University of Vermont Burlington, VT
Reprint requests to Cardiovascular Health Study, Coordinating Center, Century Square, 1501 4th Avenue, Suite 2025, Seattle, WA 98101.
The cross-sectional correlates of three hemostatic factors–fibrinogen, factor VII, and factor VIII–were examined in the Cardiovascular Health Study, a population-based cohort study of 5,201 subjects over age 65 years. Subjects were recruited in 1989–1990 in Forsyth County, North Carolina; Sacramento County, California; Washington County, Maryland; and Pittsburgh, Pennsylvania. In multivariate linear regression models, cardiac risk factors significantly associated with fibrinogen were current smoking, race, lipids, and white blood count. In women, alcohol use, obesity, physical activity, and insulin level were also significant, while in men hypertension was correlated. The significant correlates of factor VII were lipids and white blood count in men and estrogen use, alcohol use, race, lipids, insulin level, white blood count, and obesity in women. The independent correlates of factor VIII were insulin, glucose, and race in both sexes; low density lipoprotein cholesterol, white blood count, and diuretic use in men; and alcohol use in women. In multivariate models, factors known to be modifiable risk factors for cardiovascular disease accounted for more of the population variance of these hemostatic factors in women than in men, especially for factor VII. The hemostatic factors may mediate some effects of risk factors on disease, and this should be considered in longitudinal studies.
aged; blood coagulation factors; cardiovascular disease; risk factors
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