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American Journal of Epidemiology Vol. 143, No. 11: 1089-1093
Copyright © 1996 by The Johns Hopkins University School of Hygiene and Public Health


other

Alcohol Consumption and Myocardial Infarction: A Case-Control Study in France and Northern Ireland

Pedro Marques-Vidal1, Pierre Duclmetière2,, Alun Evans3, Jean-Pierre Cambou1, and Dominique Arveller4

1MONICA-Toulouse, Institut National de la Santeé et de la Recherche Médicale (INSERM) U326, Observatoire Régional de Santé Midi-Pyrénées, Centre Hospitalier Universitaire Purpan 31059 Toulouse Cedex, France
2INSERM U258, HÔipltal Broussais 96, rue Didot, 75674 Paris Cedex 14, France
3MONICA-Belfast, Department of Epidemiology and Public Health, The Queen's University of Belfast Belfast BT12 6BJ, United Kingdom
4MONICA-Strasbourg, Laboratoire d'Epidémiologie et de Santé Publique 11, rue Humann, 67085 Strasbourg Cedex, France

Reprint requests to Dr. Pierre Ducimetière, INSERM U258, Hôpital Broussais, 96, rue Didot, 75674 Pans Cedex 14, France.

The effect of alcohol consumption was assessed in 561 men with myocardial infarction and 643 healthy controls recruited from France and Northern Ireland between 1988 and 1991 in the ECTIM Study (Enquête Cas-Témoins de I'lnfarctus du Myocarde). In total, patients consumed less wine than did controls, while non-wine-derived alcohol consumption did not differ significantly. After adjustment for cardiovascular nsk factors and country of recruitment by logistic regression, alcohol consumption displayed a protective effect against myocardial infarction, the magnitude of which was comparable in both countries. This effect, which was essentially due to wine consumption in France and to nonwine consumption in Northern Ireland, was largely attenuated by the introduction of high density lipoprotein cholesterol into the model. Thus, both wine and nonwme consumption appear to exert a protective effect against myocardial infarction which is partly mediated through an increase in high density lipoprotein cholesterol. Am J Epidemiol 1996; 143: 1089–93.

alcohol drinking; alcohol; ethyl; apolipoproteins; case-control studies; lipoproteins; myocardial infarction; wine


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