American Journal of Epidemiology Vol. 142, No. 6: 608
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
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Colon Cancer and Serum Vitamin D Metabolite Levels 10–17 Years prior to Diagnosis
1Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health Bethesda, MD.
2Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD.
3Department of Pediatrics, Medical University of South Carolina Charleston, SC.
Reprint requests to Dr. M. Miles Braun, Division of Biostatistics and Epidemiology, CBER, FDA, 1401 Rockville Pike, Rockville, MD 20852-1448 (present address).
This study examines the hypothesis that low serum levels of vitamin D metabolites are associated with an increased risk for colon cancer. From August through November 1974, 20,305 residents of Washington County, Maryland, donated blood for storage at –70°C in a serum bank. Colon cancer was subsequently diagnosed among 57 of these residents during the period 1984–1991. Controls had donated blood in 1974 and remained free of colon cancer through the date ofdiagnosis of the case. Two controls were matched to each case on age (±1 year), race, sex, and date of blood draw (±1 month). Mean 25-hydroxyvitamin D levels were 23.6 ng/ml and 23.2 ng/ml, and mean 1,25-dihydroxyvitamin D levels were 34.7 pg/ml and 34.6 pg/ml, in cases and controls, respectively. Analysis by quintile of serum level similarly foundthat none of the 95% confidence intervals of the odds ratios excluded unity, and a dose-response effect was not observed. Our data provide no strong support for the hypothesis that vitamin D metabolite levels affect the subsequent risk for colon cancer. Am J Epidemiol 1995; 142:608–11.
colon; neoplasms; vitamin D
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