American Journal of Epidemiology Vol. 142, No. 3: 288-294
Copyright © 1995 by The Johns Hopkins University School of Hygiene and Public Health
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Uric Acid and Coronary Heart Disease Risk: Evidence for a Role of Uric Acid in the Obesity-Insulin Resistance Syndrome
The Normative Aging Study
1Program on Aging and Applied Gerontology, The Chicago Medical School North Chicago, IL
2Normative Aging Study, Department of Veterans Affairs Outpatient Clinic Boston, MA
3Section of Preventive Medicine and Epidemiology and the Evans Memorial Department of Clinical Research, Department of Medicine, University Hospital, Boston University School of Medicine Boston, MA
4Department of Medicine, Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School and Northwestern Memorial Hospital Chicago, IL
5Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School Boston, MA
Reprint requests to Dr. David Sparrow, Normative Aging Study, Department of Veterans Affairs Outpatient Clinic, 251 Causeway Street, Boston, MA 02114
Various epidemiologic studies have linked an increase in serum uric acid level to an increased risk of coronary heart disease. The reasons for this finding are unclear. The authors examined the influence of a number of cardiovascular disease risk factors on serum uric acid level in 886 middle-aged and older men participating in the Normative Aging Study. The men were examined between 1987 and 1991. In a multivariate regression model predicting serum uric acid level, uric acid was positively associated with body mass index (weight (kg)/height (m)2; ß = 0.041 mg/dl per kg/m2, 
= 0.003), abdomen : hip circumference ratio (ß = 1.88 mg/dl per cm/cm, = 0.048), log alcohol intake (ß = 0.150 µg/dl per g/week, = 0.0001), and log postcarbohydrate insulin level (ß = 0.157 mg/dl per log(µlU/ml), = 0.005). Serum uric acid level was negatively associated with age (ß = -0.012 mg/dl per year of age, = 0.017) and log physical activity (ß = -0.152 mg/dl per kcal/week, = 0.0001). The data suggest that serum uric acid may be involved in the obesity-insulin resistance syndrome, which in turn may explain the relation of serum uric acid to coronary atherosclerosis.
coronary disease; insulin resistance; obesity; uric acid
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