American Journal of Epidemiology Vol. 140, No. 7: 598-607
Copyright © 1994 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
DNA Repair and Susceptibility to Basal Cell Carcinoma: A Case-Control Study
1Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University Baltimore, MD
2Department of Biochemistry, School of Hygiene and Public Health, The Johns Hopkins University Baltimore, MD
3Department of Dermatology, School of Medicine, The Johns Hopkins University Baltimore, MD
Reprint requests to Dr. Qingyi Wei, Box 189, Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030
This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free derma tologic controls who had had noncancerous skin disorders diagnosed between 1987 and 1990. Logistic regression models were used to assess the independent effect of the selected variables stratified by DNA repair level, with adjustment for age and family history. Skin type, lifetime number of severe sunburns, and actinic elastosis were also selected as risk factors for basal cell carcinoma. Cryopreserved lymphocytes from 88 cases and 135 controls were used for the DNA repair assay. When data were stratified by DNA repair level and adjusted for age and family history of skin cancer, significantly increased odds ratios associated with lighter skin (odds ratio (OR) = 3.2, 95% confidence interval (Cl) 1.5–7.3), six or more severe sunburns in a lifetime (OR = 4.2, 95% Cl 1.6–10.7), and moderate or severe actinic elastosis (OR = 4.4, 95% Cl 1.5–12.8) were observed in persons with low DNA repair but not in those with high DNA repair. These findings suggest that impaired DNA repair may be a susceptibility factor for sunlight-induced skin cancer in the general public, as it is in patients with xeroderma pigmentosum.
biological markers; carcinoma; basal cell; case-control studies; DNA repair; skinneoplasms
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