American Journal of Epidemiology Vol. 140, No. 3: 262-267
Copyright © 1994 by The Johns Hopkins University School of Hygiene and Public Health
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Postmenopausal Estrogen Replacement Therapy and the Risk of Alzheimer's Disease: A Population-based Case-Control Study
1Department of Epidemiology, School of Public Health and Community Medicine, University of Washington Seattle, WA
2Central Epidemiology and Drug Safety, Medicine and Clinical Development Department, Division Pharma Ciba-Geigy Ltd , Basel, Switzerland
3Department of Pharmacy, School of Medicine, University of Washington Seattle, WA
4Department of Environmental Health, School of Public Health and Community Medicine, University of Washington Seattle, WA
5Department of Neurology, School of Medicine, University of Washington Seattle, WA
6Department of Medicine, School of Medicine, University of Washington Seattle, WA
7Department of Psychiatry, School of Medicine, University of Washington Seattle, WA
Reprint requests to Dr Daniel E Brenner, CibaGeigy Ltd., K-490.1.46, Postfach, CH-4002 Basel, Switzerland
Preliminary animal and human data suggest that estrogens may be protective against Alzheimer's disease in women. In a population-based case-control study at Group Health Cooperative of Puget Sound, Seattle, Washington, the authors compared the exposure of estrogen replacement therapy of 107 female Alzheimer's disease cases with 120 age- and sex-matched controls by using computerized pharmacy data. The cases were obtained from the Alzheimer's Disease Patient Registry of the University of Washington, Seattle, Washington, which is based on the enumerated health plan population from 1987 to 1992. Newly recognized cases of probable Alzheimer's disease according to standardized diagnostic criteria were ascertained, evaluated, and enrolled in the Registry. The controls were selected from the same defined population by stratified random sampling When the authors applied logistic regression, ever use of estrogens did not show an association with Alzheimer's disease (adjusted odds ratio = 1.1, 95 percent confidence interval 0.6–1.8). Oral and vaginal estrogens yielded similar results. In conclusion, this study provides no evidence that estrogen replacement therapy has an impact on the risk of Alzheimer's disease in women. Am J Epidemiol 1994; 140:262–7.
Alzheimer's disease; dementia; senile; estrogen replacement therapy; sex factors
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