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American Journal of Epidemiology Vol. 137, No. 11: 1190-1202
Copyright © 1993 by The Johns Hopkins University School of Hygiene and Public Health

research-article

High Plasma Insulin Level Associated with Coronary Heart Disease in the Elderly

Leena Mykk{caron}nen 1, Markku Laakso and Kalevi Pyörölö

From the Department of Medicine, University of Kuopio Kuoplo, Finland

Reprint requests to Prof. Kalevi Pyörölö, Department of Medicine, University of Kuopio, P0. Box 1627, SF-70211 Kuopio, Finland

The relation between plasma insulin level and the prevalence of coronary heart disease was studied in a representative nondiabetic population sample of 396 men and 673 women aged 65–74 years in Kuoplo, eastern Finland, in 1986–1988. No association between plasma insulin levels and the prevalence of previous myocardial infarction was seen, except for a positive relation between 2-hour insulin level and myocardial infarction in women (4.1,4.1 and 11.9%, p <0.01; insulin quintiles I+II, III+IV, and V, respectively). However, the prevalence of ischemic electrocardiographic changes increased by quintiles of fasting plasma insulin (not significant) and 2-hour plasma insulin (39.8, 50.6, and 59.5% in men, p < 0.01; 35.9, 39.0, and 53.0% in women, p < 0.01). Furthermore, the prevalence of angina pectons increased by fasting insulin (19.3, 19.0, and 33.8%, in men, p < 0.05; not significant in women) and 2-hour insulin quintiles (11.2, 28.8, and 30.4% in men, p < 0.001; 17.0, 17.8, and 28.4% in women, p < 0.05). There was a marked clustering of risk factors, including high total triglyceride levels, low high density lipoprotein cholesterol levels, and hypertension in subjects in the highest insulin quintiles. The association between insulin levels and coronary heart disease, except for myocar dial infarction in women, diminished in multivariate analyses. In conclusion, hypennsulinemia was related to an increased prevalence of coronary heart disease in elderly subjects which may be due to in part to adverse alterations in other risk factors associated with hyperinsulinemia.

aged; coronary disease; hypertension; insulin; lipids; lipoproteins

1Present address. University of Texas Health Science Center, Department of Medicine, Division of Clinical Epidemiology, 7703 Floyd Curl Drive, San Antonio, TX 78284- 7873.


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