American Journal of Epidemiology Vol. 136, No. 11: 1316-1320
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
The Relation between Multiple Births and Maternal Risk of Breast Cancer
Bureau of Cancer Epidemiology, New York State Department of Health Corning Tower, Room 565, the Governor Nelson A Rockefeller Empire State Plaza, Albany, NY 12237.
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Data from two case-control studies conducted in New York State during 1982–1986 were used to examine the relation between multiple births and the maternal risk of breast cancer. The cases were 2, 561 women between 20 and 79 years of age with a diagnosis of primary breast cancer. Controls (n=2, 616) were selected from driver's license files and matched to cases by year of birth and country of residence. The odds ratio for any multiple birth was 0.94 (95%confidence interval (Cl) 0.56–1.56) in women less than 55 years of age and 0.95 (95%Cl 0.62–1.46) in women aged 55–79 years. A previous study had shown a muliple last birth to be protective against breast cancer in women less than 55 years of age (odds ratio (OR)=0.60, 95%Cl 0.43–0.85). A decreased risk of breast cancer was also observed for this age group in the present study, but the magnitude of the effect was not as strong and the confidence interval included unity (OR = 0.85, 95% Cl 0.43–1.68). A logistic model that controlled for age at first pregnancy, number of live births, age, and county of residence increased the odds ratio to 0.97 for a multiple last birth. The current study does not support an association between multiple births and maternal risk of breast cancer. Am J Epidemiol 1992; 136;1316–20.
breast neoplasms; case-control studies; pregnancy; multiple
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