American Journal of Epidemiology Vol. 135, No. 9: 981-988
Copyright © 1992 by The Johns Hopkins University School of Hygiene and Public Health
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Principal Lifetime Occupation and Cognitive Impairment in a French Elderly Cohort (Paquid)
1Inserm U 330, Université de Bordeaux I Bordeaux, France
Reprint requests to Dr. Jean Francois Dartigues, Inserm U 330, Universite de Bordeaux II, 146 Rue Leo Saignat, 33076 Bordeaux Cedex, France
The purpose of the present study was to examine the relation between principal lifetime occupation and cognitive performance with the initial data collected (1988–1989) in a cohort of 3, 777 community residents of the area of Bordeaux, France, aged 65 years and older. Subjects were considered as cognitively impaired if they scored under 24 on the French version of the mini-mental state examination. Cognitive impairment was found to vary significantly across the different occupational categories. Results of the logistic regression show that age, sex, and educational level are significantly related to cognitive impairment. Moreover, after controlling for these and other covariates, farmworkers (odds ration (OR) = 6.1, 95% confidence interval (CI) 3.3–11.4), farm managers (OR = 2.9, 95% CI 1.6–5.1), domestic service employees (OR = 2.8, 95% CI 1.5–5.1), and blue-collar workers (OR = 2.5, 95% CI 1.4–4.4) had a higher risk of cognitive impairment than did subjects who had an intellectual occupation. Follow-up of the cohort will permit precise determination of the role of principal lifetime occupation in subsequent cognitive deterioration. Occupational status should be taken into consideration when studying brain aging. Am J Epidemiol 1992; 135: 981–8
aged; cognition; educational status; occupations
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