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American Journal of Epidemiology Vol. 134, No. 9: 942-947
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health

research-article

The Association of Blood Pressure with Cancer Incidence in a Prospective Study

John S. Grove1, Abraham Nomura2,, Richard K. Severson3 and Grant N. Stemmermann2

1Biostatistics Program Department of Public Health Sciences, School of Public Health, University of Hawaii Honolulu, HI
2Japan-Hawaii Cancer Study, Kuakini Medical Center Honolulu, HI
3Divisions of Epidemiology and Pediatric Oncology, University of Minnesota Minneapotis, MN

Reprint requests to Dr. Abraham Nomura at the Japan-Hawaii Cancer Study, 347 N Kuakini Street, Honolulu, HI 96817

A cohort of 8,006 Japanese-American men living in Hawaii was examined from 1965 to 1968 and followed for about 20 years. The study identified 1,155 incident cases of histologically confirmed cancer and 648 deaths due to cancer. There was no association between systolic or diastolic blood pressure and total cancer incidence or deaths due to cancer. The relative risk was 1.03 for cancer incidence and 1.00 for cancer mortality for subjects with a systolic pressure of 160 mmHg or greater. Adjustment was made for age, smoking, alcohol, and measures related to obesity. When cancers of specified sites were studied, blood pressure was positively associated with the incidence of kidney cancer (17 cases). After adjustment for the significant effect of taking antihypertensive medication, the effect of blood pressure became nonsignificant. Among seven other cancer sites, there were no statistically significant associations with blood pressure after adjustment for confounding factors.

blood pressure; cohort studies; hypertension; incidence; kidney neoplasms; neoplasms


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