American Journal of Epidemiology Vol. 134, No. 3: 257-267
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Blood Pressure, the Prevalence of Cardiovascular Diseases, and Exposure to Cadmium: A Population Study
1Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven Leuven, Belgium.
2Industrial Toxicology and Occupational Medicine Unit, University of Louvain Brussels, Belgium
3Institute of Hygiene and Epidemiology, Ministry of Health and Social Affairs Brussels, Belgium.
4Division of Geriatric Medicine, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital London, United Kingdom.
5Environmental Toxicology Unit, University of Liège Liège, Belgium.
Reprint request to Dr. J. Staessen, Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde-Cardiologie, U.Z. Gasthisberg, Herestraat 49,B-3000 Leuven, Belgium
In a population study conducted from 1985 to 1989 in Belgium, the authors investigated whether exposure to cadmium is associated with blood pressure elevation and with an increased prevalence of cardiovascular diseases. The participants, aged 20–88 years, constituted a random sample of the households living in two low exposure areas(n = 803) and two high exposure areas (n = 1,283). For each exposure level, a rural and an urban district were selected. The cadmium levels in blood (8.5 vs. 11.0 nmol/liter) and urine (7.2 vs. 8.7 nmol/24 hours) were significantly (p < 0.001) raised in the two high exposure areas compared with the two low exposure areas (p < 0.001). Systolic pressure was similar in both rural areas, but in the urban area with high exposure systolic pressure was 5 mmHg (p < 0.001) higher than in the control town. Diastolic pressure was similar in the four districts and the same was true for the prevalence of hypertension and of other cardiovascular diseases. Adjustment of systolic pressure for blood and urinary cadmium did not remove the difference in systolic pressure between both urban areas, suggesting that it was not related to the cadmium burden on the environment. Further analyses in individual subjects showed that neither blood pressure nor the presence of cardiovascular diseases were significantly and positively correlated with blood and urinary cadmium. Thus, the present population study did not confirm the hypothesis that increased exposure of the population to cadmium is associated with blood pressure elevation and with a higher prevalence of cardiovascular diseases. Am J Epidemiol 1991;134:257–67.
blood pressure; cadmium; cardiovascular diseases; coronary disease; hypertension; lead
*Deceased.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R Schutte, T Nawrot, T Richart, L Thijs, H A Roels, L M Van Bortel, H Struijker-Boudier, and J A Staessen Arterial structure and function and environmental exposure to cadmium Occup. Environ. Med., June 1, 2008; 65(6): 412 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sirivarasai, S. Kaojarern, W. Wananukul, W. Deechakwan, and P. Srisomerarn Non-occupational Lead and Cadmium Exposure and Blood Pressure in Thai Men Asia Pac J Public Health, January 1, 2004; 16(2): 133 - 137. [Abstract] [PDF]
|
|
|
|
|
|
J. A Staessen, E. T O'Brien, L. Thijs, and R. H Fagard Modern approaches to blood pressure measurement Occup. Environ. Med., August 1, 2000; 57(8): 510 - 520. [Abstract] [Full Text]
|
|