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American Journal of Epidemiology Vol. 133, No. 7: 715-720
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health

research-article

A Preliminary Study of Excess Risk of Cardiovascular Disease in the Mothers of Patients with Rheumatoid Arthritis

David Kaplan1, and Joseph Feldman2

1Rheumatalogy Division, Department of Medicine, State University of New York, Health Science Center at Brooklyn Brooklyn, NY
2Department of Preventive Medicine and Community Health, State University of New York, Health Science Center at Brooklyn Brooklyn, NY

Reprint requests to Dr. David Kaplan, Department of Medicine, State University of New York, Health Science Center at Brooklyn, 450 Clarkson Avenue, Box 42, Brook lyn, NY 11203

Family histories were obtained from 123 patients with rheumatoid arthritis and 152 patients with other musculoskeletal complaints. The subjects were female patients aged 40 years or more seen at the Arthritis Clinic of the State University of New York Health Science Center at Brooklyn between October 1985 and February 1986. It was found that death due to heart disease or stroke was more common (adjusted p < 0.02) in the mothers of patients with rheumatoid arthritis than in the mothers of control patients, and that heart disease was also reported to be more common in these mothers (adjusted p < 0.005). Thus, it is possible that cardiovascular disease at least partially accounts for the previously noted (J Rheumatol 1986;13:903–6) shorter life expectancy of the mothers of patients with rheumatoid arthritis.

arthritis; rheumatoid; cardiovscular disease; mothers; rheumatoid factor


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