American Journal of Epidemiology Vol. 133, No. 6: 554-559
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Endometrial Cancer and Age at Last Delivery: Evidence for an Association
1Stone Epidemiology Unit, School of Public Health, Boston University School of Medicine Brookline, MA
2The Clinical Epidemiology Unit, University of Pennsylvania School of Medicine Philadelphia, PA
3Memorial Sloan-Kettering Cancer Center New York, NY
Reprint requests to Dr. Samuel M. Lesko, Slone Epidemiology Unit, 1371 Beacon Street, Brookline, MA 02146
Because the role hormonal and reproductive factors play in the etiology of endometrial cancer is incompletely understood, the authors evaluated the risk of this cancer in relation to age at last delivery. The data were obtained in a hospital-based case-control study of 483 women with endometrial cancer (cases) and 693 women with other conditions (controls) conducted in a number of hospitals in the United States and Canada from 1978 to 1985. There was an inverse association between age at last delivery and endometrial cancer risk: Compared with women who last gave birth before age 25 years, the rate ratio was 0.9 (95% confidence interval (CI) 0.5–1.6) for last delivery at ages 25–29 years, 0.6 (95% CI 0.3–1.0) for last delivery at ages 30–34 years, 0.5(95% CI 0.3–1.0) for last delivery at ages 35–39 years, and 0.4(95% CI 0.1–0.9) for last delivery at age 40 years or older. The trend of decreasing rate ratio with increasing age at last delivery was statistically significant (p = 0.02). The association was apparent regardless of parity or menopausal status. There was no evidence for an association between age at first pregnancy and risk. These data suggest that women who bear children late in reproductive life may be at lower risk for endometrial cancer than those who complete their families early.
incidence; pregnancy; risk factors; uterine neoplasms; etiology
4 Current address: New York Hospital, New York, NY.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. A. Smith, A. C. von Eschenbach, R. Wender, B. Levin, T. Byers, D. Rothenberger, D. Brooks, W. Creasman, C. Cohen, C. Runowicz, et al. American Cancer Society Guidelines for the Early Detection of Cancer: Update of Early Detection Guidelines for Prostate, Colorectal, and Endometrial Cancers: ALSO: Update 2001--Testing for Early Lung Cancer Detection CA Cancer J Clin, January 1, 2001; 51(1): 38 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Salazar-Martinez, E. C. Lazcano-Ponce, G. G. Lira-Lira, P. E.-D. los Rios, J. Salmeron-Castro, and M. Hernandez-Avila Reproductive Factors of Ovarian and Endometrial Cancer Risk in a High Fertility Population in Mexico Cancer Res., August 1, 1999; 59(15): 3658 - 3662. [Abstract] [Full Text] [PDF]
|
|