American Journal of Epidemiology Vol. 133, No. 2: 123-132
Copyright © 1991 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
Prenatal Exposure to Parents' Smoking and Childhood Cancer
1Department of Epidemiology, School of Public Health, University of North Carolina Chapel Hill, NC
2Current address. Department of Health Research and Policy, Stanford University School of Medicine Stanford, CA
3Epidemiology Branch, Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences Research Triangle Park, NC
Reprint requests to Esther M John, Department of Health Research and Policy, Stanford University School of Medicine, HAP Buitding, Surte 8, Stanford, CA 94305-5092
The relation between parents' tobacco smoking prior to birth and cancer in the offspring was investigated with the use of data from a case-control study. Incident cases included all children (aged 0–14 years) diagnosed in Denver, Colorado from 1976 to 1983. Controls were selected through random digit dialing, and matched to cases on age, sex, and geographic area. Information on smoking by parents and other household members was obtained by personal interview for 223 cases and 196 controls. After adjustment for father's education, mother's smoking during the first trimester of pregnancy was associated with an increased nsk for all cancers combined (odds ratio (OR) = 1.3, 95% confidence interval (Cl) 0.7–2.1), acute lymphocytic leukemia (OR = 1.9, 95% Cl 0.9–4.1), and lyrnphomas (OR = 2.3, 95% Cl 0.8–7.1). Adjusting for father's education, associations with father's smoking in the absence of mother's smoking were found for all cancers combined (OR = 1.2, 95% Cl 0.8–2.1), acute lymphocytic leukemia (OR = 1.4, 95% Cl 0.6–3.1), tymphomas (OR = 1.6, 95% 0.5–5.4), and brain cancer (OR = 1.6, 95% Cl 0.7–3.5). In spite of imprecision resulting from small numbers of cases in diagnostic subgroups, these results are suggestive of a possible influence of parents' smoking on childhood cancer. Am J Epidemiol 1991133:123-32.
brain neoplasms; child; leukemia; smoking
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Best, Committee on Environmental Health, Committee on Native American Child Health, and Committee on Adolescence Secondhand and Prenatal Tobacco Smoke Exposure Pediatrics, November 1, 2009; 124(5): e1017 - e1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Whitehead, C. Metayer, M. H. Ward, M. G. Nishioka, R. Gunier, J. S. Colt, P. Reynolds, S. Selvin, P. Buffler, and S. M. Rappaport Is House-Dust Nicotine a Good Surrogate for Household Smoking? Am. J. Epidemiol., May 1, 2009; 169(9): 1113 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yu, B. Mahadevan, C. V. Lohr, K. A. Fischer, M. A. Louderback, S. K. Krueger, C. B. Pereira, D. J. Albershardt, W. M. Baird, G. S. Bailey, et al. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene Carcinogenesis, October 1, 2006; 27(10): 2116 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Chang, S. Selvin, C. Metayer, V. Crouse, A. Golembesky, and P. A. Buffler Parental Smoking and the Risk of Childhood Leukemia Am. J. Epidemiol., June 15, 2006; 163(12): 1091 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Mucci, F. Granath, and S. Cnattingius Maternal Smoking and Childhood Leukemia and Lymphoma Risk among 1,440,542 Swedish Children Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1528 - 1533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Bertone, L. A. Snyder, and A. S. Moore Environmental Tobacco Smoke and Risk of Malignant Lymphoma in Pet Cats Am. J. Epidemiol., August 1, 2002; 156(3): 268 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lu, S. Tong, and B. Oldenburg Determinants of smoking and cessation during and after pregnancy Health Promot. Int., December 1, 2001; 16(4): 355 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nelson The miseries of passive smoiong Human and Experimental Toxicology, February 1, 2001; 20(2): 61 - 83. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Zhang, D. L. Weddle, P. E. Thomas, B. Zheng, A. Castonguay, H. M. Schuller, and M. S. Miller Low Levels of Expression of Cytochromes P-450 in Normal and Cancerous Fetal Pancreatic Tissues of Hamsters Treated with NNK and/or Ethanol Toxicol. Sci., August 1, 2000; 56(2): 313 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J Sasco and H. Vainio From in utero and childhood exposure to parental smoking to childhood cancer: a possible link and the need for action Human and Experimental Toxicology, April 1, 1999; 18(4): 192 - 201. [Abstract] [PDF]
|
|
|
|
 |
|
 A. J. Thornton and P. N. Lee Review : Parental Smoking and Risk of Childhood Cancer: A Review of the Evidence Indoor and Built Environment, March 1, 1998; 7(2): 65 - 86. [Abstract] [PDF]
|
|
|
|
 |
|
 R. C. Brownson, T. E. Novotny, and M. C. Perry Cigarette Smoking and Adult Leukemia: A Meta-analysis Arch Intern Med, February 22, 1993; 153(4): 469 - 475. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Florig Containing the costs of the EMF problem Science, July 24, 1992; 257(5069): 468 - 469. [PDF]
|
|
|
|
 |
|
 J. M. Pollock-Byrne and A. V. Merlo Against Compulsory Treatment: No "Quick Fix" For Pregnant Substance Abusers Criminal Justice Policy Review, June 1, 1991; 5(2): 79 - 99. [Abstract]
|
|