American Journal of Epidemiology Vol. 132, No. 2: 248-256
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
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CHLAMYDIA PNEUMONIAE STRAIN TWAR, MYCOPLASMA PNEUMONIAE, AND VIRAL INFECTIONS IN ACUTE RESPIRATORY DISEASE IN A UNIVERSITY STUDENT HEALTH CLINIC POPULATION
1Department of Epidemiology, School of Public Health and Community Medicine, University of Washington Seattle, WA
2Department of Pathobiology, School of Public Health and Community Medicine, University of Washington Seattle, WA
3David Hall Student Health Center and Department of Family Medicine, University of Washington Seattle, WA
Reprint requests to Dr. J. Thomas Grayston, Department of Epidemiology SC-36, University of Washington, Seattle, WA 98195
Clinical and serologic data were collected on 667 University of Washington students who presented to the David Hall Student Health Center between 1983 and 1987 with acute respiratory disease. Sera were tested for evidence of acute or past infections with Chlamydia pneumoniae strain TWAR, Chlamydia trachomatis, Mycoplasma pneumoniae, influenza A virus, influenza B virus, adenovirus, and respiratory syncytial virus. Pharyngeal swab specimens were cultured for C. pneumoniae and C. trachomatls, but not for the other agents. Evidence of acute infection with C. pneumoniae was found in 20 patients and evidence of an acute infection with M. pneumoniae in 29 patients. C. pneumoniae was associated with 9% and M. pneumoniae with 11% of 149 pneumonias diagnosed clinically, and with 20% and 22%, respectively, of the 59 pneumonias confirmed on chest radiograph. There was no evidence of seasonality in C. pneumoniae or M. pneumoniae infections. Compared with patients with M. pneumoniae, patients with C. pneumoniae were less likely to have a temperature greater than 37.8°C (10% vs. 34%), but were more likely to present with a sore throat (80% vs. 52%) or hoarseness (30% vs. 3%). The mean number of days from onset of symptoms until enrollment was longer in patients with C. pneumoniae infections than in those with M. pneumoniae (12.8 vs. 7.9 days), or those with a viral infection (12.8 vs. 7.3 days), suggesting a more gradual onset of disease caused by C. pneumoniae.
bronchitis; chlamydia infections; pneumonia; mycoplasma; pneumonia; viral
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