American Journal of Epidemiology Vol. 132, No. 1: 136-143
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
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COGNITIVE IMPAIRMENT AND MORTALITY: A STUDY OF POSSIBLE CONFOUNDERS
1Epidemiology, Demography, and Biometry Program, National Institute of Aging Bethesda, MD
2Center for Health Studies, Group Health Cooperative of Puget Sound, and Department of Epidemiology, University of Washington Seattle, WA
3Department of Neurology, University of Maryland School of Medicine Baltimore, MD
4Department of Neurology, Boston University School of Medicine Boston, MA
Reprint requests to Dr. Ingrid Y. Liu, Room 618, Federal Building, National Institutes of Health, Bethesda, MD 20892
Baseline neuropsychological function was assessed in 2,123 Framingham Heart Study participants and was related to mortality over an 8- to 10-year follow-up period. During that time, 573 persons died. Using Cox proportional hazards models, the authors showed poor cognitive function to be consistently associated with an increased risk of death. This association persisted after adjustment for the confounding effects of age, education, and illness. Subjects scoring below the 26th percentile of performance were at increased risk of mortality compared with high scorers (the relative risk was 1.3 for the 11th percentile-25th percentile and 1.7 for the 1st percentile-10th percentile).
aged; cognition; geriatric psychiatry; mortality
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