American Journal of Epidemiology Vol. 131, No. 4: 633-643
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
SENSORY NEUROPATHY IN NON-INSULIN-DEPENDENT DIABETES MELLITUS
THE SAN LUIS VALLEY DIABETES STUDY
1Department of Neurolo University of Colorado School of Medicine Denver, CO
2Rocky Mountain Multiple Sclerosis Center, University of Colorado School of Medicine Denver, CO
3Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine Denver, CO
Reprint requests to Dr. Gary M. Franklin, San Luis Valley Diabetes Study, University of Colorado School of Medicine, Box C245, 4200 E. 9th Avenue, Denver, CO 80262
A screening neurologic examination capable of detecting distal symmetric (sensory) neuropathy in a large population-based study of non-insulin-dependent diabetes mellitus in San Luis Vafley, Colorado, in 1984–1986 is described and validated. The examination, completed in 279 diabetIcs and 577 controls, had 90% agreement with a standard neurologic examination completed on a subsam ple of 38 patients. Independent validation of neuropathy status was obtained with the Optacon tactile (vibration) stimulator. Mean, age-adjusted vibration threshold was significantly greater in those with neuropathy than in those without The subtests of the examination most sensitive in detecting neuropathy were a combination of a positive history of neuropathy symptoms and decreased or absent deep tendon reflexes in both ankles. Age-adjusted prevalence of neurop athy in controls, those with impaired glucose tolerance, and diabetics was 3.9%, 11.2%, and 25.8%, respectively. Prevalence odds ratios were 3.5 and 10.6 for the presence of neuropathy in persons with Impaired glucose tolerance and diabetes, respectively, compared with persons with normal glucose tolerance. Neuropathy was significantly associated with age, duration of diabetes, male sex, and glycemic control, but not with Anglo/Hispanic status.
diabetes mellitus; non-insulin dependent; hemoglobin A; glycosylated; Hispanic Americans; neurologic examination; peripheral nerve diseases; restrospective studies
4Present address: Department of Environmental Health, SC-34, University of Washington School of Public Health and Community Medicine, Seattle, WA.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. J. Garber Combined Pharmacologic/Nonpharmacologic Intervention in Individuals at High Risk of Developing Type 2 Diabetes: Pro pharmacologic therapy Diabetes Care, November 1, 2009; 32(suppl_2): S184 - S188. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Perrin and H. Swerissen The Behavior and Psychological Functioning of People at High Risk of Diabetes-Related Foot Complications The Diabetes Educator, May 1, 2008; 34(3): 493 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S F E Praet, R A M Jonkers, G Schep, C D A Stehouwer, H Kuipers, H A Keizer, and L J van Loon Long-standing, insulin-treated type 2 diabetes patients with complications respond well to short-term resistance and interval exercise training Eur. J. Endocrinol., February 1, 2008; 158(2): 163 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Koopman, A. G. Mainous III, H. A. Liszka, J. A. Colwell, E. H. Slate, M. A. Carnemolla, and C. J. Everett Evidence of Nephropathy and Peripheral Neuropathy in US Adults With Undiagnosed Diabetes. Ann. Fam. Med, September 1, 2006; 4(5): 427 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Kissel Peripheral Neuropathy With Impaired Glucose Tolerance: A Sweet Smell of Success? Arch Neurol, August 1, 2006; 63(8): 1055 - 1056. [Full Text] [PDF]
|
|
|
|
|
|
E. L.M. Barr, T. Y. Wong, R. J. Tapp, C. A. Harper, P. Z. Zimmet, R. Atkins, J. E. Shaw, and on behalf of the AusDiab Steering Committee Is Peripheral Neuropathy Associated With Retinopathy and Albuminuria in Individuals With Impaired Glucose Metabolism?: The 1999-2000 AusDiab Diabetes Care, May 1, 2006; 29(5): 1114 - 1116. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Dyck, P. C. O'Brien, W. J. Litchy, C. M. Harper, C. J. Klein, and P. J. B. Dyck Monotonicity of Nerve Tests in Diabetes: Subclinical nerve dysfunction precedes diagnosis of polyneuropathy Diabetes Care, September 1, 2005; 28(9): 2192 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tesfaye, N. Chaturvedi, S. E.M. Eaton, J. D. Ward, C. Manes, C. Ionescu-Tirgoviste, D. R. Witte, J. H. Fuller, and the EURODIAB Prospective Complications Study Group Vascular Risk Factors and Diabetic Neuropathy N. Engl. J. Med., January 27, 2005; 352(4): 341 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. K. Klein, R. Klein, P. E. McBride, K. J. Cruickshanks, M. Palta, M. D. Knudtson, S. E. Moss, and J. O. Reinke Cardiovascular Disease, Mortality, and Retinal Microvascular Characteristics in Type 1 Diabetes: Wisconsin Epidemiologic Study of Diabetic Retinopathy Arch Intern Med, September 27, 2004; 164(17): 1917 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Gregg, P. Sorlie, R. Paulose-Ram, Q. Gu, M. S. Eberhardt, M. Wolz, V. Burt, L. Curtin, M. Engelgau, and L. Geiss Prevalence of Lower-Extremity Disease in the U.S. Adult Population >=40 Years of Age With and Without Diabetes: 1999-2000 National Health and Nutrition Examination Survey Diabetes Care, July 1, 2004; 27(7): 1591 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R. Holland and C. I. Prodan Peripheral Neuropathy and "Borderline" Diabetes J Am Board Fam Med, March 1, 2004; 17(2): 127 - 130. [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Singleton, A. G. Smith, J. W. Russell, and E. L. Feldman Microvascular Complications of Impaired Glucose Tolerance Diabetes, December 1, 2003; 52(12): 2867 - 2873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-F. Kuo, M. A. Raji, K. S. Markides, L. A. Ray, D. V. Espino, and J. S. Goodwin Inconsistent Use of Diabetes Medications, Diabetes Complications, and Mortality in Older Mexican Americans Over a 7-Year Period: Data from the Hispanic Established Population for the Epidemiologic Study of the Elderly Diabetes Care, November 1, 2003; 26(11): 3054 - 3060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Reiber, D. G. Smith, C. Wallace, K. Sullivan, S. Hayes, C. Vath, M. L. Maciejewski, O. Yu, P. J. Heagerty, and J. LeMaster Effect of Therapeutic Footwear on Foot Reulceration in Patients With Diabetes: A Randomized Controlled Trial JAMA, May 15, 2002; 287(19): 2552 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Singleton, A. G. Smith, and M. B. Bromberg Increased Prevalence of Impaired Glucose Tolerance in Patients With Painful Sensory Neuropathy Diabetes Care, August 1, 2001; 24(8): 1448 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Harris Racial and Ethnic Differences in Health Care Access and Health Outcomes for Adults With Type 2 Diabetes Diabetes Care, March 1, 2001; 24(3): 454 - 459. [Abstract] [Full Text]
|
|
|
|
|
|
S. O. Oyibo, E. B. Jude, I. Tarawneh, H. C. Nguyen, L. B. Harkless, and A. J.M. Boulton A Comparison of Two Diabetic Foot Ulcer Classification Systems: The Wagner and the University of Texas wound classification systems Diabetes Care, January 1, 2001; 24(1): 84 - 88. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. E. Resnick, A. I. Vinik, H. K. Heimovitz, F. L. Brancati, and J. M. Guralnik Age 85+ Years Accelerates Large-Fiber Peripheral Nerve Dysfunction and Diabetes Contributes Even in the Oldest-Old: The Women's Health and Aging Study J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2001; 56(1): 25M - 31. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Lavery, D. G. Armstrong, S. A. Vela, T. L. Quebedeaux, and J. G. Fleischli Practical Criteria for Screening Patients at High Risk for Diabetic Foot Ulceration Arch Intern Med, January 26, 1998; 158(2): 157 - 162. [Abstract] [Full Text] [PDF]
|
|