American Journal of Epidemiology Vol. 131, No. 3: 468-482
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health
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CANCER MORTALITY AND LIPID AND LIPOPROTEIN LEVELS
THE LIPID RESEARCH CLINICS PROGRAM MORTALITY FOLLOW-UP STUDY
1Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center Oklahoma City, OK
2Centre for Clinical Epidemiology and Biostatistics, Faculty of Medicine, University of Newcastle Newcastle, New South Wales, Australia
3Department of Community and Family Medicine, School of Medicine, University of California at San Diego La Jolla, CA
4Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health Baltimore, MD
5Department of Preventive Medicine and Environmental Health, College of Medicine, University of Iowa Iowa City, LA
The associations of serum lipid and lipoprotein levels with the risk of cancer mortality were assessed in 2,753 men and 2,476 women aged 40–79 years at baseline (1972–1976) who participated in the Lipid Research Clinics Program Mortality Follow-up Study through 1984. Seventy-nine cancer deaths occurred in men and 65 occurred in women during an average follow-up time of 8.4years. Total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly inversely associated with overall cancer mortality in men, but no relation was observed in women. Neither high-density lipoprotein (HDL) cholesterol nor tri-gtycerides were significantly related to total cancer mortality in either sex, although in women, HDL cholesterol was positively associated with risk of death from gynecologic cancers. Compared with men with higher cholesterol levels, the relative risk of death from colon cancer, adjusted for age, body mass, cigarette smoking, and alcohol consumption, was 5.20 (95 percent confidence interval (Cl) 1.61–16.8) in men with total cholesterol levels 
87 mg/dl and 4.79 (95 percent Cl 1.37–16.8) in those with LDL cholesterol levels 119 mg/dl. Death from smoking-related cancers was inversely related to baseline total cholesterol but not to LDL cholesterol. The absence of an association with HDL cholesterol, which has been shown to be lower in persons with clinically manifest malignancy, and evidence from survival curves suggest that the inverse relation in men is not due to preexisting disease.
cholesterol; lipids; lipoproteins; lipoproteins, HDL cholesterol; lipoproteins, LDL cholesterol; mortality; neoplasms; triglycerides
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