Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by HOUSTON, S.
Right arrow Articles by FRASER, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOUSTON, S.
Right arrow Articles by FRASER, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 131, No. 2: 340-348
Copyright © 1990 by The Johns Hopkins University School of Hygiene and Public Health

research-article

THE EFFECTIVENESS OF BACILLUS CALMETTE-GUERIN (BCG) VACCINATION AGAINST TUBERCULOSIS

A CASE-CONTROL STUDY IN TREATY INDIANS, ALBERTA, CANADA

STAN HOUSTON1, ANNE FANNING2,, COLIN L. SOSKOLNE3 and NONIE FRASER4

1University of Zimbabwe, Department of Clinical Pharmacology Harare, Zimbabwe
2Department of Medicine. University of Alberta Edmonton, Alberta, Canada
3Department of Health Services Administration and Community Medicine, University of Alberta Edmonton, Alberta, Canada
4Edmonton Board of Health Edmonton, Alberta, Canada

Reprint requests to Dr. Anne Fanning, Division of Infectious Diseases, Department of Medicine, 2E4.11 Walter MacKenzie Health Sciences Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2B7

Bacillus Calmette-Guérin (BCG) vaccination against tuberculosis has been used around the world for 60 years, yet its efficacy in large, controlled prospective studies is inconsistent. The factors influencing BCG protection include variation in immunogenic potential, background exposure to environmental mycobactena, and differences in host response to vaccine. As a means of addressing regional differences in protection, case-control studies provide a relatively inexpensive, rapid means of assessing regional vaccine effects. Treaty Indian cases (n = 160) resident in Alberta, Canada, presenting during a 5-year period (1975–1979) were individually matched for age, sex, and Band with two nontuberculous controls. A 57 percent protection by BCG vaccination was demonstrated. These results support the usefulness of case-control studies and their importance in planning tuberculosis control programs.

BCG vaccine; Indians, North American; population; public health; retrospective studies; tuberculosis; vaccination


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int J EpidemiolHome page
A. Roth, P. Gustafson, A. Nhaga, Q. Djana, A. Poulsen, M.-L. Garly, H. Jensen, M. Sodemann, A. Rodriques, and P. Aaby
BCG vaccination scar associated with better childhood survival in Guinea-Bissau
Int. J. Epidemiol., June 1, 2005; 34(3): 540 - 547.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
G. A. Colditz, T. F. Brewer, C. S. Berkey, M. E. Wilson, E. Burdick, H. V. Fineberg, and F. Mosteller
Efficacy of BCG Vaccine in the Prevention of Tuberculosis: Meta-analysis of the Published Literature
JAMA, March 2, 1994; 271(9): 698 - 702.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.