American Journal of Epidemiology Vol. 129, No. 4: 687-702
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health
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THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUI)Y: DESIGN AND OBJECTWES
Atherosclerosis Risk in Communities (ARIC) is a new prospective study to investigate the etiology of atherosclerosis and its clinical sequelae and variation in cardiovascular risk factors, medical care, and disease by race, sex, place, and time. in each of four US communities—Forsyth County, North Carolina, Jackson, Mississippi, suburbs of Minneapolis, Minnesota, and Washington County, Maryland—4, 000 adults aged 45–64 years will be examined twice, three years apart. ARIC has coordinating, ultrasound, pulmonary, and electrocardiographic centers and three central laboratories. Three cohorts represent the ethnic mix of their communities; the Jackson cohort, its black population. Examinations include ultrasound scanning of carotid and popliteal arteries; lipids, lipoprotelns, and apolipoproteins assayed in the Lipid Laboratory; and coagulation, inhibition, and platelet and fibrinolytic actmty assayed in the Hemostasis Laboratory. Surveil lance for coronary heart disease will involve review of hospitalizations and deaths among community residents aged 35–74 years. ARIC aims to study atheroscle rosis by direct observation of the disease and by use of modem biochemistry.
arteriosclerosis; cardiovascular diseases; coronary disease; hemostasis; Ilpoproteins
1The ARIC Steering Committee: Department of Epidemiology, The Johns Hopkins University, Balti more, MD—Moyses Szklo, Chairperson; Bowman Gray School of Medicine, Winston-Salem, NC—Ralph Barnes; Division of Epidemiology, University of Minnesota, Minneapolis, MN—Aaron Folsom; De partment of Epidemiology, University of North Car olina, Chapel Hill, NC—Gerardo Heiss; Department of Medicine, University of Mississippi Medical Center, Jackson, MS—Richard Hutchinson; Department of Internal Medicine, Baylor College of Medicine, Houston, TX—Wolfgang Patach; Epidemiology and Biom etry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD—A. Richey Sharrett Department of Biostatistics, Uni versity of North Carolina, Chapel Hill, NC—O. Dale Williams; Division of Hematology-Oncology, University of Texas Medical School at Houston, Houston, TX— Kenneth Wu
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