Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by NORDENSTAM, G.
Right arrow Articles by EDÉN, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NORDENSTAM, G.
Right arrow Articles by EDÉN, C. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Vol. 129, No. 1: 89-96
Copyright © 1989 by The Johns Hopkins University School of Hygiene and Public Health

other

AGE-RELATED CHANGE IN ANTI-CARBOHYDRATE ANTIBODY LEVELS

G. NORDENSTAM1,3, B. ANDERSSON1, C. BENGTSSON3, D. BRILES4, G. SCOTT4, A. SVANBORG2 and C. SVANBORG EDÉN1

1Department of Clinical Immunology, Goteborg University Guldhedsgatan 10 A. S-413 46, Goteborg, Sweden
2Department of Primary Health Care, Goteborg University Goteborg, Sweden
3Department of Geriatrics and Long-term Care Medicine, Goteborg University Goteborg, Sweden
4Department of Microbiology and Immunology, University of Alabama Birmingham, AL

Nordenstam, G., B. Andersson, C. Bengtsson, D. Briles, G. Scott, A. Svanborg, and C. Svanborg Eden (Dept of Clinical Immunology, U. of Gdteborg, S-413 46, Göteborg, Sweden). Age-related change in anti-carbohydrate antibody levels. Am J Epidemiol 1989;129:89–96.

It has been proposed that immunity declines with age Most evidence for this hypothesis has been obtained from cross-sectional samples of unrelated populations that differ in age, antigen exposure, and morbidity. In the present study, the authors used serum samples collected repeatedly from the same persons In longitudinal studies. Two representative samples of the population in Gateborg, Sweden were obtained; the first was studied at ages 38, 50, and 62 years, and the second at ages 70, 75, 79, and 81 years, respectively. The phosphoryicholine determinant of pr, eumococcai teichoic acid and the B blood group determinant were selected as model polysaccharide antigens. The results demonstrate a consistent declIne In individual antibody levels in the decades before age 70 years but not later. Antibodies to phosphoryicholine and blood group B were highly parallel, suggesting that the decline was a general phenomenon for antibodies to polysaccharlde antigens.

antibodies; blood groups; immunity; phosphoryicholine


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
D. Purkall, J. G. Tew, and H. A. Schenkein
Opsonization of Actinobacillus actinomycetemcomitans by Immunoglobulin G Antibody Reactive with Phosphorylcholine
Infect. Immun., November 1, 2002; 70(11): 6485 - 6488.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.