American Journal of Epidemiology Vol. 128, No. 3: 515-523
Copyright © 1988 by The Johns Hopkins University School of Hygiene and Public Health
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SERUM LEVELS OF SELENIUM AND RETINOL AND THE SUBSEQUENT RISK OF CANCER
1Public Health Sciences Division, The Fred Hutch inson Cancer Research Center Seattle, WA
3Neutron Activation Laboratory, University of Missouri, Columbia MO
4Department of Laboratory Medicine, University of Washington Seattle, WA
Reprint requests to Dr. Ralph J. Coates, Emory University School of Medicine, 246 Sycamore Street, Suite 100, Decatur, GA 30030
A nested case-control study was conducted to assess the relation between serum levels of selenium and retinol and the subsequent risk of cancer. During the years 1972–1984, in northwest Washington State, 156 cases of cancer were identified among members of two employee cohorts from whom specimens had been previously obtained and stored. Two hundred eighty-seven controls were selected from these cohorts and matched to cases on the basis of employer, age, sex, race, and date of blood draw. Selenium and retinal levels were mea sured by neutron activation and high pressure liquid chromatography, respectively. Information on known cancer risk factors was collected by telephone interviews of subjects and next of kin. Levels of selenium and retinal were unassociated with the incidence of cancer of all sites combined, both overall and within subgroups defined by age, sex, levels of the other micronutrient, time between blood draw and diagnosis, smoking status, and family history of cancer. These findings suggest that neither serum levels of selenium nor those of retinal have an appreciable effect on the risk of cancer.
neoplasms; nutrition; preventive medicine; retinol; selenium; vitamin A
2Present address: Department of Community Health, Emory University School of Medicine, Atlanta, GA.
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