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American Journal of Epidemiology Vol. 126, No. 1: 112-117
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
CIGARETTE SMOKING AND THE RISK OF EPITHELIAL OVARIAN CANCER1
Reprint requests to Dr. Adele L. Franks
Cigarette smoking may affect each of the currently proposed mechanisms of ovarian carcinogenesis. Whether cigarette smoking has any effect on the development of ovarian cancer has not been adequately evaluated. To study this issue, the authors examined data from the Cancer and Steroid Hormone Study, a multicenter, case-control study of gynecologic cancers conducted between December 1, 1980, and December 31, 1982, in eight geographic areas of the United States. This analysis utilized data on 494 women with newly diagnosed epithelial ovarian cancer and 4,238 population-based control women 2054 years of age. There was no association of epithelial ovarian cancer with dose of cigarette smoking, age smoking started, time since smoking started, or time since smoking last occurred. Simultaneous adjustment for age, parity, history of oral contraceptive use, and other potentially confounding factors did not alter these results.
ovarian neoplasms; smoking
1 From the Division of Reproductive Health, Center for Health Promotion and Education, Centers for Disease Control, Atlanta, GA 30333.
2 The Cancer and Steroid Hormone Study Group: Principal Investigator-George L. Rubin; Project Director-Phyllis A. Wingo; Project Associates-Nancy C. Lee, Michele G. Mandel, Herbert B. Peterson. Data Collection Centers Principal Investigators: Atlanta- Raymond Greenberg; Connecticut-J. Wister Meigs, W. Douglas Thompson; Detroit-G. Marie Swanson; Iowa-Elaine Smith; New Mexico-Charles Key, Dorothy Pathak; San Francisco-Donald Austin; Seattle-David Thomas; Utah-Joseph Lyon, Dee West Pathology Review Principal Investigators: Fred Gor-stein, Robert McDivitt, Stanley J. Robboy. Project Consultants: Lonnie Burnett, Robert Hoover, Peter M. Layde, Howard W. Ory, James J. Schlesselman, David Schottenfeld, Bruce Stadel, Linda A. Webster, Colin White. Pathology Consultants: Walter Bauer, William Christopherson, Deborah Gereell, Robert Kunnan, Allen Paris, Frank Vellios.