American Journal of Epidemiology Vol. 125, No. 3: 437-444
Copyright © 1987 by The Johns Hopkins University School of Hygiene and Public Health
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SPIROMETRY VARIABILITY CRITERIA-ASSOCIATION WITH RESPIRATORY MORBIDITY AND MORTALITY IN A COHORT OF COAL MINERS
1Department of Preventive Medicine and Community Health, University of Illinois College of Medicine at Chicago, Health Sciences Center P.O. Box 6998, Chicago, IL 60680
2Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown WV
Reprint requests to Dr. Shirley E. Kellie
To clarify the association between spirometry variability and respiratory morbidity and mortality, the authors analyzed data for miners examined in the first round of the National Coal Study, 1969–1971, and they compared groups of miners who failed with those who met each of two spirometry variability criteria: a 5% criterion recommended by the American Thoracic Society, and a 200 ml criterion used in prior research studies. Compared with miners who met the 5% criterion (the best two forced vital capacities must be within 5% or 100 ml of one another), the group that failed had a lower moan for forced expiratory volume in one second (FEV1), and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.75, 1.67, 1.76, 2.71, and 1.30, respectively. The findings for the 200 ml criterion (the best two FEV1s must be within 200 ml of one another) were somewhat different The group that failed versus the group that met this criterion had a higher moan for FEV1, and odds ratios for cough, phlegm, wheeze, shortness of breath, and death of 1.13, 1.07, 1.15, 1.43, and 0.94, respectively. Although the findings differ for the two criteria, the findings demonstrate that increased spirometry variability is associated with poorer health.
pneumoconiosis; respiratory function tests; spirometry
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