American Journal of Epidemiology Vol. 124, No. 6: 894-902
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
DIET AND PANCREATIC CANCER: A CASE-CONTROL STUDY
RAN JACOBSON3RNBERG6
1Department of Epidemiology, The National Institute of Environmental Medicine Box 60208, S-104 01 Stockholm, Sweden
2Department of Surgery, Danderyd University Hospital Danderyd, Sweden
3Department of Surgery, Uppsala University Hospital Uppsala, Sweden
4Department of Social Medicine, Huddinge University Hospital Huddinge, Swden
5Preventive Unit for Occupational Medicine, Royal Institute of Technology Stockholm, Sweden
6Department of Pathology, Sdersjukhuset, Stock Stockholm, Sweden
7Department of Hepatobiliary and Pancreatic Diseases Sodersjukhuset, Stockholm, Sweden
1 Send reprint requests to Dr. Staffan Norell at this address
Norell, S. E. (The National Institute of Environmental Medicine, Box 60208, S 104 01 Stockholm, Sweden), A. Ahlbom, R. Erwald, G. Jacobson, I. Undberg Navier, R. Olin, B. Tornberg, and K-L. Wiechel. Diet and pancreatic cancer a case-control study. Am J Epklemlol 1986;124:894–902
In a population-based case-control study carried out In Sweden in 1982-1984, the authors examined the association of pancreatic cancer with several dietary factors, coffee, alcohol, and tobacco. Analyses were based on 99 cases, 138 population controls, and 163 hospital controls. The cases were persons aged 40–79 years diagnosed with cancer of the exocrine pancreas at three surgical departments in Stockholm and Uppsala. The risk increased with higher consump tion frequency of fried and grilled meat in the comparison with each series of controls (e.g., relative risk (AR) = 1.7 (90% confIdence Interval (Cl) = 1.1–2.7) for weekly Intake and RR = 13.4 (90% Cl=2.4-74.7) for almost daily intake, In the comparison with population controls). Furthermore, associations were found with other fried or grilled foods, but not with meat other than fried or grilled. The risk also increased with the intake of margarine (e.g., AR = 9.7 (90% Cl = 3.1–30.2) for 15+ g of margarine on a slice of bread, in the comparison with population controls). In contrast, no excess risk was associated with hIgh intake of butter. A low risk was associated with frequent consumption of fruits and vegetables, particularly carrots (RR = 0.3(90% Cl = 0.2–0.7)) and citrus fruits (RR = 0.5(90% Cl = 0.3–0.9)) for almost daily intake. No consistent associations were found with coffee, artificial sweeteners or alcohol consumption, but a threefold Increase In risk was associated with smokIng at least one pack of cigarettes per day.
alcohol; coffee; diet; pancreatic neoplasms; tobacco
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