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American Journal of Epidemiology Vol. 124, No. 6: 884-893
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health

research-article

URINARY MUTAGENS IN MUNICIPAL SEWAGE WORKERS AND WATER TREATMENT WORKERS

JANET M. SCARLETT-KRANZ1, JOHN G. BABISH1, DANIEL STRICKLAND2, RENEE M. GOODRICH3 and DONALD J. LISK3

1Department of Veterinary Preventive Medicine, New York State College of Veterinary Medicine, Cornell University Ithaca, NY
2Veterinary Diagnostic Laboratory, New York State College of Veterinary Medicine, Cornell University Ithaca, NY
3Toxic Chemicals Laboratory, New York State College of Agriculture and Life Sciences, Cornell University Ithaca, NY 14853-7401

Scarlett-Kranz, J. M., J. G. Babish, D. Strickland, H. M. Goodrich, and D. J. Lisk (Cornell U., Toxic Chemicals Laboratory, Ithaca, NY 14853-7401). Urinary muta gens in municipal sewage workers and water treatment workers. Am J Epldemlol 1986; 124:884-93.

In view of the potential exposure of sewage treatment workers to a multftude of mutagenic substances, the frequency of urinary mutagens was measured by the Ames test among a sample of 164 sewage treatment workers employed in 14 sewage treatment plants which processed between 3 and 10 mIllion gallons of sewage daily in New York State between March and July, 1984. The frequency was compared to that observed in 72 water treatment employees In the same municipalities. Sewage workers had a significantly higher risk for urinary muta gens after controlling for smoking, using the Ames test both with and without the addition of the liver microsomal homogenate, S-9. More precise methods of measuring exposure in epidemiologic studies, particularly in environmental and occupational epidemiology, are in various stages of development The application of one of these methods, the Ames test, to an occupational group (sewage workers) with potentially high exposure to mutagenic substances Is described and the strengths and limitations of this application are discussed.

mutagens; occupational diseases; sewage; water; urine


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