American Journal of Epidemiology Vol. 123, No. 5: 781-789
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
SERUM RETINOL AND RETINOL-BINDING PROTEIN LEVELS DO NOT PREDICT SUBSEQUENT LUNG CANCER
1Department of Medical Methods Research, Kaiser Permanente Medical Care Program 3451 Piedmont Avenue, Oakland, CA 94611
2Department of Medicine, College of Physicians and Surgeons, Columbia University New York, NY
3Orentreich Foundation for the Advancement of Science, Inc. New York, NY
4Division of Cancer Cause and Prevention, National Cancer Institute Bethesda, MD
Reprint requests to Dr. Gary D. Friedman
Retinol and retinol-binding protein levels were measured in sera previously obtained, and stored in the frozen state, at multiphasic health checkups from 151 persons subsequently found to have lung cancer (cases) and 302 persons who remained free of cancer (controls). Two controls were matched to each case for sex, skin color, age, date of multiphasic health checkup, and aspects of the smoking habit. Mean levels in cases and controls were, respectively, retinol: 82.17 and 82.37 µg/dl (p=0.93), and retinol-binding protein: 6.04 and 6.00 µg/dl (p=0.81). Mean differences between cases and controls were, retinol: 0.195 µg/dl with 95% confidence limits, –3.91 and 4.30 µg/dl; retinol-binding protein: –0.033 µg/dl with 95% confidence limits, –0.31 and 0.24 µg/dl. No significant trend in relative risk of lung cancer was observed when the retinol or retinol-binding protein distribution was divided into quintiles. No significant associations were observed in subgroups based on age, sex, histologic type of cancer, cigarette consumption, or interval between blood drawing and cancer diagnosis. In this large study, retinol and retinol-binding protein levels were not useful in predicting the subsequent development of lung cancer.
lung neoplasms; retinol; retinol binding proteins; vitamin A
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