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American Journal of Epidemiology Vol. 123, No. 2: 261-269
Copyright © 1986 by The Johns Hopkins University School of Hygiene and Public Health

research-article

A PSYCHIATRIC EPIDEMIOLOGIC STUDY OF OCCUPATIONAL LEAD EXPOSURE

DAVID K. PARKINSON1,, CHRISTOPHER RYAN2, EVELYN J. BROMET2 and MELANIE M. CONNELL2

1Department of Medicine, University of Pittsburgh School of Medicine Pittsburgh, PA 15213
2Department of Psychiatry, University of Pittsburgh School of Medicine Pittsburgh, PA

Reprint requests to Dr. David K. Parkinson

The association of occupational lead exposure with neuropsychiatric functioning was evaluated using data collected in 1982 in eastern Pennsylvania from 288 lead-exposed workers and 181 nonexposed subjects. Both current and cumulative exposure indices were used. After controlling for age, education, and income, few meaningful differences between exposed and control workers were found on either neuropsychologic or psychosocial variables. Dose-response analyses indicated that among lead-exposed workers, cumulative and current exposure were unrelated to neuropsychologic performance. The only meaningful associations occurred between exposure and level of conflict in interpersonal relationships. The results thus give evidence against hypotheses suggesting adverse neuropsychologic effects.

lead; nervous system diseases


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