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American Journal of Epidemiology Vol. 122, No. 3: 378-385
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

TRACE METALS AND CORONARY HEART DISEASE RISK INDICATORS IN 152 ELDERLY MEN (THE ZUTPHEN STUDY)

D. KROMHOUT1,, A. A. E. WIBOWO2, R. F. M. HERBER2, L. M. DALDERUP3, H. HEERDINK1, C. DE LEZENNE COULANDER1 and R. L. ZIELHUIS2

1Institute of Social Medicine, Faculty of Medicine, State University of Leiden P.O. Box 9605, 2300 RC Leiden, The Netherlands
2Coronel Laboratory for Occupational and Environmental Health, Faculty of Medicine, University of Amsterdam Amsterdam, The Netherlands
3Factory Inspectorate, Ministry of Social Affaire Amsterdam, The Netherlands

Reprint requests to Dr. D. Kromhout at this address

Information about trace metals and coronary heart disease risk indicators was collected in 1977 among 152 men aged 57–76 years in the town of Zutphen, the Netherlands. Serum zinc, serum copper, blood cadmium, and blood lead were determined by atomic absorption spectrometry and serum lithium by flame emission spectrometry. After uni- and muttivariate regression analysis, the following statistically significant relations were found: serum zinc was inversely related to resting heart rate; serum copper was positively related to cigarette smoking and inversely to high density lipoprotein cholesterol; blood cadmium was strongly positively related to cigarette smoking and inversely to Quetelet index; the positive relation between blood lead and cigarette smoking was of borderline significance; and blood lead was related to blood pressure, with the relation being stronger for systolic than for diastolic blood pressure.

blood pressure; cadmium; cholesterol; copper; coronary disease; lead; smoking; zinc


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