American Journal of Epidemiology Vol. 122, No. 2: 276-282
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
SERUM SELENIUM AND THE RISK OF CORONARY HEART DISEASE AND STROKE
1National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland
2Research Department, Finnish Heart Association Helsinki, Finland
Reprint requests to Dr. Jarmo Virtamo
The association between serum selenium concentration and five-year risk of cardiovascular disease was studied in 1,110 men aged 55 to 74 years in two rural areas of Finland. In the total cohort, all-cause and cardiovascular deaths were associated significantly with serum selenium of less than 45 µg/liter, an adjusted relative risk of 1.4 (95% confidence interval (Cl), 1.0–2.0, p<0.05) and 1.6 (957percnt; Cl, 1.1–2.3, p<0.05), respectively. Among men free of coronary heart disease at the outset, these associations were of similar magnitude but did not attain statistical significance. Among men free of stroke at the outset, low serum selenium was associated significantly with stroke mortality, an adjusted relative risk of 3.7 (95% Cl, 1.0–13.1). The associations of coronary deaths and myocardial infarctions with low serum selenium were nonsignificant.
cerebrovascular disorders; coronary disease; selenium
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Manati, F. Vaillant, M. Bost, V. Maffre, D. Belhani, J. Descotes, A. Tabib, B. Bui-Xuan, L. Hamdan, and Q. Timour Protective role of selenium supplementation against cardiac lesions induced by the combination of levomepromazine and risperidone in the rabbit Human and Experimental Toxicology, August 1, 2009; 28(8): 461 - 467. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Laclaustra, A. Navas-Acien, S. Stranges, J. M. Ordovas, and E. Guallar Serum Selenium Concentrations and Hypertension in the US Population Circ Cardiovasc Qual Outcomes, July 1, 2009; 2(4): 369 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bleys, A. Navas-Acien, M. Laclaustra, R. Pastor-Barriuso, A. Menke, J. Ordovas, S. Stranges, and E. Guallar Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004 Am. J. Epidemiol., April 15, 2009; 169(8): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Hawkes and L. J. Laslett Selenium supplementation does not improve vascular responsiveness in healthy North American men Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H256 - H262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Boosalis The Role of Selenium in Chronic Disease Nutr Clin Pract, April 1, 2008; 23(2): 152 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Q. Rich, J. M. Gaziano, and T. Kurth Geographic Patterns in Overall and Specific Cardiovascular Disease Incidence in Apparently Healthy Men in the United States Stroke, August 1, 2007; 38(8): 2221 - 2227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Nawrot, J. A. Staessen, H. A. Roels, E. Den Hond, L. Thijs, R. H. Fagard, A. F. Dominiczak, and H. A. Struijker-Boudier Blood pressure and blood selenium: a cross-sectional and longitudinal population study Eur. Heart J., March 1, 2007; 28(5): 628 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Flores-Mateo, A. Navas-Acien, R. Pastor-Barriuso, and E. Guallar Selenium and coronary heart disease: a meta-analysis. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 762 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Stranges, J. R. Marshall, M. Trevisan, R. Natarajan, R. P. Donahue, G. F. Combs, E. Farinaro, L. C. Clark, and M. E. Reid Effects of Selenium Supplementation on Cardiovascular Disease Incidence and Mortality: Secondary Analyses in a Randomized Clinical Trial Am. J. Epidemiol., April 15, 2006; 163(8): 694 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rajpathak, E. Rimm, J. S. Morris, and F. Hu Toenail Selenium and Cardiovascular Disease in Men with Diabetes J. Am. Coll. Nutr., August 1, 2005; 24(4): 250 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Ross, J.-M. Yuan, B. E. Henderson, J. Park, Y.-T. Gao, and M. C. Yu Prospective Evaluation of Dietary and Other Predictors of Fatal Stroke in Shanghai, China Circulation, July 1, 1997; 96(1): 50 - 55. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. J. Kok, A. Hofman, J. C. M. Witteman, A. M. d. Bruijn, D. H. C. M. Kruyssen, M. d. Bruin, and H. A. Valkenburg Decreased Selenium Levels in Acute Myocardial Infarction JAMA, February 24, 1989; 261(8): 1161 - 1164. [Abstract] [PDF]
|
|
|
|
 |
|
 J. E. Morley, A. D. Mooradian, A. J. Silver, D. Heber, and R. B. Alfin-Slater Nutrition in the Elderly Ann Intern Med, December 1, 1988; 109(11): 890 - 904. [Abstract] [PDF]
|
|