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American Journal of Epidemiology Vol. 121, No. 2: 238-245
Copyright © 1985 by The Johns Hopkins University School of Hygiene and Public Health

research-article

ESTROGEN REPLACEMENT THERAPY AND FIBROCYSTIC BREAST DISEASE IN POSTMENOPAUSAL WOMEN1

GERTRUD S. BERKOWITZ2,, JENNIFER L. KELSEY3, THEODORE R. HOLFORD4, VIRGINIA A. LIVOLSI5, MARIA J. MERINO6, GERALD J. BECK4, SHARON ORT7, THERESA Z. O'CONNOR4 and COLIN WHITE4

2Department of Obstetrics, Gynecology, and Reproductive Science, and Community Medicine, The Mount Sinai Medical Center New York, NY
3Division of Epidemiology, Columbia University School of Public Health New York, NY
4Department of Epidemiology and Public Health, Yale University School of Medicine New Haven, CT
5Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Philadelphia, PA
6Department of Pathology, Yale University School of Medicine New Haven, CT
7Child Study Center, Yale University School of Medicine New Haven, CT

Reprint requests to Dr. Gertrud S. Berkowitz, Department of Obstetrics, Gynecology, and Reproductive Science, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029

The association between estrogen replacement therapy and fibrocystic breast disease was assessed in a hospital-based case-control study undertaken in Connecticut from 1979 to 1981. The cases were 143 postrnenopausal women with biopsy-confirmed fubrocystic breast disease, and the controls were 355 postmenopausal women with other surgical conditions. Use of estrogen replacement therapy was positively associated with fibrocystic breast disease; the odds of disease increased with duration of use, reaching an approximately fivefold excess odds for those who had taken menopausal estrogens for 10 or more years. There was no evidence that the positive association between estrogen replacement therapy and the occurrence of fibrocystic breast disease could be explained by differential medical care utilization or other possible risk factors of biopsied flbrocystic breast disease.

breast diseases; estrogens

1 From the Departments of Epidemiology and Public Health, and Pathology, Yale University School of Medicine, New Haven, CT.


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