American Journal of Epidemiology Vol. 120, No. 4: 518-530
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health
research-article |
GENETIC AND ENVIRONMENTAL DETERMINANTS OF LEVEL OF PULMONARY FUNCTION
1Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital Boston, MA
2Division of Infectious Diseases, Department of Medicine, Harvard Medical School, Beth Israel Hospital Boston, MA
3Division of Biostatistics, Washington University School of Medicine St. Louis, MO
4Medical Service, Veteran's Administration Medical Center Brockton, MA
Reprint requests to Dr. Ira B. Tager, Channing Laboratory, 180 Longwood Ave., Boston, MA 02115
Measurements of level of pulmonary function (one second forced expiratory volume (FEV1) and forced expiratory flow between the 25% and 75% volume points (FEF25–75) were obtained on members of 404 nuclear families living in East Boston, Massachusetts In 1974. These families were ascertained through a random sample of children aged 5–9 years. Measurements were obtained on family members on three separate occasions during a 5-year period. These data were subjected to the techniques of path analysts to study the relative contributions of heredity and environment to individual levels of pulmonary function. Genetic heritability was found to be consistent through time (41–47%) and was the same for parents and their children. Common familial environmental effects on levei of pulmonary function explained 1–4% of the variability in children and 11–28% in adults. Furthermore, we were able to confirm prior epidemiologic analysis of these data which have demonstrated an effect of maternal smoking on the level of pulmonary function in their children.
family characteristics; genetics; respiratory function test
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J-Q. He, K. Shumansky, J. E. Connett, N. R. Anthonisen, P. D. Pare, and A. J. Sandford Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD Eur. Respir. J., July 1, 2008; 32(1): 25 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J-Q. He, K. Shumansky, X. Zhang, J. E. Connett, N. R. Anthonisen, and A. J. Sandford Polymorphisms of interleukin-10 and its receptor and lung function in COPD Eur. Respir. J., June 1, 2007; 29(6): 1120 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Wilk, A. Herbert, C. M. Shoemaker, D. J. Gottlieb, and S. Karamohamed Secreted Modular Calcium-binding Protein 2 Haplotypes Are Associated with Pulmonary Function Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 554 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Silverman Progress in chronic obstructive pulmonary disease genetics. Proceedings of the ATS, July 1, 2006; 3(5): 405 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Reinhard, B. Meyer, H. Fuchs, T. Stoeger, G. Eder, F. Ruschendorf, J. Heyder, P. Nurnberg, M. H. de Angelis, and H. Schulz Genomewide Linkage Analysis Identifies Novel Genetic Loci for Lung Function in Mice Am. J. Respir. Crit. Care Med., April 15, 2005; 171(8): 880 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. Functional Genomics of Lung Disease Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81. [Full Text] [PDF]
|
|
|
|
 |
|
 D L DeMeo, V J Carey, H A Chapman, J J Reilly, L C Ginns, F E Speizer, S T Weiss, and E K Silverman Familial aggregation of FEF25-75 and FEF25-75/FVC in families with severe, early onset COPD Thorax, May 1, 2004; 59(5): 396 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y J Cheng, C A Macera, C L Addy, F S Sy, D Wieland, and S N Blair Effects of physical activity on exercise tests and respiratory function Br. J. Sports Med., December 1, 2003; 37(6): 521 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Malhotra, A. P. Peiffer, D. T. Ryujin, T. Elsner, R. E. Kanner, M. F. Leppert, and S. J. Hasstedt Further Evidence for the Role of Genes on Chromosome 2 and Chromosome 5 in the Inheritance of Pulmonary Function Am. J. Respir. Crit. Care Med., September 1, 2003; 168(5): 556 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-I. Ho, H.-J. Harn, C.-J. Chen, and N.-M. Tsai Polymorphism of the {beta}2-Adrenoceptor in COPD in Chinese Subjects Chest, November 1, 2001; 120(5): 1493 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. GOTTLIEB, J. B. WILK, M. HARMON, J. C. EVANS, O. JOOST, D. LEVY, G. T. O'CONNOR, and R. H. MYERS Heritability of Longitudinal Change in Lung Function . The Framingham Study Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1655 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.J. Palmer, M.W. Knuiman, M.L. Divitini, P.R. Burton, A.L. James, H.C. Bartholomew, G. Ryan, and A.W. Musk Familial aggregation and heritability of adult lung function: results from the Busselton Health Study Eur. Respir. J., April 1, 2001; 17(4): 696 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen Genetics and pulmonary medicine bullet 10: Genetic epidemiology of pulmonary function Thorax, September 1, 1999; 54(9): 818 - 824. [Full Text]
|
|
|
|
|
|
C. J. HOLBERG, W. J. MORGAN, A. L. WRIGHT, and F. D. MARTINEZ Differences in Familial Segregation of FEV1 between Asthmatic and Nonasthmatic Families . Role of a Maternal Component Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 162 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. SILVERMAN, H. A. CHAPMAN, J. M. DRAZEN, S. T. WEISS, B. ROSNER, E. J. CAMPBELL, W. J. O'DONNELL, J. J. REILLY, L. GINNS, S. MENTZER, et al. Genetic Epidemiology of Severe, Early-onset Chronic Obstructive Pulmonary Disease . Risk to Relatives for Airflow Obstruction and Chronic Bronchitis Am. J. Respir. Crit. Care Med., June 1, 1998; 157(6): 1770 - 1778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. GIVELBER, N. N. COUROPMITREE, D. J. GOTTLIEB, J. C. EVANS, D. LEVY, R. H. MYERS, and G. T. O'CONNOR Segregation Analysis of Pulmonary Function among Families in the Framingham Study Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1445 - 1451. [Abstract] [Full Text]
|
|