American Journal of Epidemiology Vol. 120, No. 3: 331-341
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health
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A DESCRIPTIVE STUDY OF NEURITIC PLAQUES AND NEUROFIBRILLARY TANGLES IN AN AUTOPSY POPULATION
1Department of Epidemiology, School of Public Health, University of Michigan Ann Arbor, MI
2Department of Pathology, School of Medicine, University of Michigan Ann Arbor, MI
3Department of Biostatistics, School of Public Health, University of Michigan Ann Arbor, MI
Send reprint requests to Dr. F. DeWolfe Miller, Department of Public Health Sciences, School of Public Health, Biomedical Sciences Building, Court D, 1960 East West Road, University of Hawaii, Honolulu, HI 96822
From July 1, 1980 to December 2, 1982, all individuals at autopsy at the University of Michigan Medical Center 
65 years of age and selected Indlvlduals <65 years of age were examined for neurltlc plaques and neurofibrillary tangles. Sections of the hippocampal, parahippcampal temporal gyrus, and fuslform gyrus were examined. In a total population of 199, each individual was classified as having none, few, or many of each lesion. The frequency of the joint presence of many plaques and tangles increased monotonically after age 71 years. There was no significant difference in the jolnt distribution of these lesions with sex or race. There was a strong correlatlon between the presence of one lesion and the other; the correlation for the two lesions was similar for males and females, but for blacks, It was significantly higher than for nonblacks. The distribution of these lesions in autopsy populations may be usetul in identifying other related hypothetical risk factors for dementla of Alzheimer's type.
Alzheimer's disease; autopsy; neurofibrils
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