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American Journal of Epidemiology Vol. 119, No. 6: 975-996
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

other

THE COLLABORATIVE LIPID RESEARCH CLINICS PROGRAM FAMILY STUDY

IV. FAMILIAL ASSOCIATIONS OF PLASMA LIPIDS AND LIPOPROTEINS

KADAMBARI K. NAMBOODIRI1, PHILIP P. GREEN1, ELLEN B. KAPLAN1, JOHN A. MORRISON2, GARY A. CHASE3, ROBERT C. ELSTON4, A. R. G. OWEN5, BASIL M. RIFKIND6,, CHARLES J. GLUECK2 and HERMAN A. TYROLER7

1Department of Biostatistics, University of North Carolina Chapel Hill, NC
2Department of Internal Medicine, University of Cincinnati, College of Medicine Cincinnati, OH
3Department of Health Services Administration, The Johns Hopkins University School of Medicine and Public Health Baltimore, MD
4Department of Biometry, Louisiana State University Medical Center ew Orleans, LA
5Lipid Research Clinic, University of Toronto Toronto, Ontario, Canada
6Lipid Metabolism-Atherogenesis Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Federal Bldg., Rm. 401, Be-thesda, MD 20205.
7Department of Epidemiology, University of North Carolina Chapel Hill, NC

(Reprint requests to Dr. Basil M. Rifkind.)

Namboodiri, K. K., P. P. Green, E. B. Kaplan, J. A. Morrison, G. A. Chase, R. C. Elston, A. R. G. Owen, B. M. Rifklnd (NHLBI, NIH, Bethesda, MD 20205), C. J. Glueck and H. A. Tyroler. The Collaborative Lipid Research Clinics Program Family Study. IV. Familial associations of plasma lipids and lipoproteins. Am J Epidemiol 1984; 119: 975–96.

Familial associations of total cholesterol, low density lipoproteln cholesterol, triglycerides, and very low density lipoprotein cholesterol were examined in a population-based random sample of 858 white and 73 black probands and their 4,027 white and 245 black relatives from nine North American Lipid Research Clinics. Correlations among biologic relatives were highly significant for total cholesterol and low density lipoprotein cholesterol and to a lesser extent for triglycerides and very low density lipoprotein cholesterol in whites. Correlations for spouses, however, were not significant, suggesting a stronger influence of genes than shared environment in the determination of these traits. Homogeneity of familial correlations across age strata, clinics, and racial groups was examined. In general, correlations were homogeneous across age strata and clinics, and there was no asymmetry in parent-offspring correlations by the sex of the parent or offspring. Racial differences in correlations were not significant except in four of 32 comparisons, with blacks showing weaker correlations than whites in those instances.

environment; family characteristics; genes; lipids; lipoproteins


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