American Journal of Epidemiology Vol. 119, No. 6: 959-974
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health
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THE COLLABORATIVE LIPID RESEARCH CLINICS PROGRAM FAMILY STUDY
III. TRANSFORMATIONS AND COVARIATE ADJUSTMENTS OF LIPID AND LIPOPROTEIN LEVELS
1Department of Biostatistics, University of North Carolina Chapel Hill, NC
2Laboratory of Physioiogical Hygiene, University of Minnesota Minneapolis, MN
3Department of Preventive Medicine and Biostatistics, University of Toronto Toronto, Ontario, Canada
4Department of Health Services Administration, The Johns Hopkins University School of Medicine and Public Health Baitimore, MD
5Department of Biometry, Louisiana State University Medical Center New Orieans, LA
Address reprint requests to Dr. Basli M. Rifkind, Lipid Metabolism-Atherogenesis Branch, NHLBI, National Institutes of Health, Federal Bidg., Rm. 401, Bethesda, MD 20205.
Green, P. P., K. K. Namboodiri (Dept of Biostatistics, U. of North Carolina, Chapei Hill, NC 27514), P. Hannan, J. Martin, A. R. G. Owen, G. A. Chase, E. B. Kapian, L. Williams and R. C. Eiston. The Coliaborative Lipid Research Clinics Program Famliy Study. III. Transformations and covariate adjustments of lipid and lipoprotein levels. Am J Epidemiol 1984; 119: 959–74.
Several methods of transformation and covarlate adjustment have been applied to the Coliaborative Lipid Research Clinics Program Famliy Study data to facilitate analysis of lipld levels of examinees of different sex and age groups. After several exploratory analyses, choiesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were logarithmicaily transformed, and triglycerides were transformed by the power –0.25. Two types of covariate adjustment procedures, the regression and Z score methods, were used. A modified regression method was developed and was found to be preferabie to both simple cubic regression and the Z score method on theoretical and empirical grounds. Refinements in this method to correct for change in variance with age, and for the effect of socioeconomic status, seasonaliy, and anthropometric measures were made. Methodoiogical Issues connected with the transformation and adjustment procedures are discussed.
epidemiologic methods; family characteristics; lipids; lipoproteins; statistics
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