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American Journal of Epidemiology Vol. 119, No. 6: 931-943
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health

other

THE COLLABORATIVE LIPID RESEARCH CLINICS PROGRAM FAMILY STUDY: I. STUDY DESIGN AND DESCRIPTION OF DATA

FAMILY STUDY COMMITTEE FOR THE LIPID RESEARCH CLINICS PROGRAM 1 2

Family Study Committee for the Lipid Research Clinics Program (NHLBI, NIH, Bethesda, MD 20205). The Collaborative Lipid Research Clinics Program Family Study. I. Study design and description of data. Am J Epidemiol 1984;119:931–43.

The third phase of the Lipld Research Clinics North American Population Studies is the Collaborative Family Study (1975–1978), designed to contribute knowledge of the familial association of dysllpoprotelnemia and distribution of lipids and lipoprotelns among family members. The 2, 405 probands of the study were composed of a random (40%) and a hyperilpldemic (60%) component. A total of 15, 693 living relatives of these probands were Identified, of whom about 75% participated in the study. Demographic, medical, and medication history and lipld and lipoproteln data were collected with strict adherence to a common protocol and standardized laboratory methodology. This report presents the design and scope of the Family Study and the distribution of probands and relatives by clinic, age, selection scheme, and family structure. The possible avenues of analysis and the potential usefulness of this large, high quality data base in assessing the familial determinants of lipld and lipoproteln levels are discussed.

data collection; family characteristics; genetics; liplds; lipoprotelns

1Lipid Metabolism-Atherogenesis Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Federal Bldg., Rm. 401, Be-thesda, MD 20205. (Reprint requests to Dr. Basil M. Rifkind at this address.)

2This manuscript was prepared by Kadambari Namboodiri, Philip Green, Deborah Dawson, Melissa Austin, Kathe Kelly, Lynn Williams, Ellen Kaplan, Richard Mowery, C. J. Glueck, Marek Macio-lowski, H. A. Tyroler, R. C. Elston, Ratna Thomas, Basil Rifkind, and W. J. Schull.


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