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American Journal of Epidemiology Vol. 119, No. 5: 788-795
Copyright © 1984 by The Johns Hopkins University School of Hygiene and Public Health


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ASSOCIATION OF CHILDHOOD LEUKEMIA WITH MATERNAL AGE, BIRTH ORDER, AND PATERNAL OCCUPATION

A CASE-CONTROL STUDY

GARY SHAW1, ROBERT LAVEY1, RICHARD JACKSON1, and DONALD AUSTIN2

1Epidemiological Studies Section, State of California, Department of Health Services Berkeley, CA
2San Francisco Bay Area Resource for Cancer Epidemiology, State of California, Department of Health Services Emeryville, CA

Reprint requests to Dr. Richard Jackson, Epidemiological Studies Section, State of California, Department of Health Services, 2151 Berkeley Way, Berkeley, CA 94704.

Shaw, G., R. Lavey, R. Jackson (Epidemiological Studies Section, Dept. of Health Services, Berkeley, CA 94704) and D. Austin. Association of childhood leukemia with maternal age, birth order, and paternal occupation: a case-control study. Am J Epidemiol 1984; 119: 788–95.

Previous investigations have drawn conflicting conclusions concerning the association between childhood leukemia and maternal age, birth order, socio-economic status, and paternal occupation. In this study, 255 childhood leukemia cases diagnosed in California between 1975 and 1980 were individually matched with two living controls on the basis of sex, date of birth, and county of birth. Data were derived from subjects' birth certificates. Socioeconomic status and paternal benzene exposure were determined from the paternal occupation stated on the birth certificate. Hispanics and males were overrepre-sented in the case group. Cases were also less likely to be of birth order one. No difference was found between case and control groups for maternal age or paternal occupation. Analyses with stratification on age, sex, and leukemia cell type are reported.

benzene; environmental exposure; leukemia; retrospective studies


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